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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150469/
Mar 24, 2014 · Finally, since hypoxia is one of the characteristics of drug-resistant cancers, hypoxia-targeted co-delivery of a chemotherapeutic drug and siRNA against the hypoxia principal effector, hypoxia inducible factor 1α, could allow relapse-free destruction of some of …Author: Federico Perche, S. Biswas, T. Wang, L. Zhu, L. Zhu, V. Torchilin
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201308368
Altered vasculature and the resultant chaotic tumor blood flow lead to the appearance in fast‐growing tumors of regions with gradients of oxygen tension and acute hypoxia (less than 1.4 % oxygen).1 Due to its roles in tumorigenesis and resistance to therapy, hypoxia represents a problem in cancer therapy.1, 2 Insufficient delivery of therapeutic ...Author: Federico Perche, S. Biswas, T. Wang, L. Zhu, L. Zhu, V. Torchilin
https://www.researchgate.net/publication/260272315_Hypoxia-Targeted_siRNA_Delivery
Request PDF Hypoxia-Targeted siRNA Delivery Altered vasculature and the resultant chaotic tumor blood flow lead to the appearance in fast-growing tumors of regions with gradients of oxygen ...
https://www.deepdyve.com/lp/wiley/hypoxia-targeted-sirna-delivery-L5yIGy3hvd
Dec 24, 2015 · Altered vasculature and the resultant chaotic tumor blood flow lead to the appearance in fast‐growing tumors of regions with gradients of oxygen tension and acute hypoxia (less than 1.4 % oxygen).1 Due to its roles in tumorigenesis and resistance to therapy, hypoxia represents a problem in cancer therapy.1, 2 Insufficient delivery of therapeutic agents to the hypoxic regions in solid tumors …
http://europepmc.org/articles/PMC4150469
Mar 01, 2014 · Finally, since hypoxia is one of the characteristics of drug-resistant cancers, hypoxia-targeted co-delivery of a chemotherapeutic drug and siRNA against the hypoxia principal effector, hypoxia inducible factor 1α, could allow relapse-free destruction of some of …
https://www.sciencedirect.com/science/article/abs/pii/S1742706116304251
To our knowledge, the described work is the first demonstration of a siRNA delivery system using a hypoxia trigger for regulation of siRNA release, which represents a new strategy for tumor-targeted therapy, and it is expected that this meaningful strategy must be widely applied in the future.Author: Lin Kang, Bo Fan, Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Zhonggao Gao
https://www.sciencedirect.com/science/article/pii/S016836591400025X
Altogether, the hybrid micelles are a promising strategy for the systemic delivery of siRNA to various and whole tumor tissues/cells. 3.4. In vivo luciferase gene silencing in transgenic mice. Pancreatic cancer is considered to be one of the most fatal cancers .Author: Frederico Pittella, Horacio Cabral, Yoshinori Maeda, Peng Mi, Sumiyo Watanabe, Hiroyasu Takemoto, Hy...
https://pubs.acs.org/doi/abs/10.1021/nn204240b
Here, we develop a ternary small interfering RNA (siRNA) delivery system with tumor acidity-activated sheddable PEG layer to overcome the challenge. The sheddable nanoparticle is fabricated by introducing a tumor acidity-responsive PEGylated anionic polymer to the surface of positively charged polycation/siRNA complexes via electrostatic interaction.Author: Xian-Zhu Yang, Jin-Zhi Du, Shuang Dou, Cheng-Qiong Mao, Hong-Yan Long, Jun Wang
https://link.springer.com/article/10.1007%2Fs10439-016-1578-6
Feb 29, 2016 · Hypoxia is a typical hallmark of various diseases, including cancer, ischemic diseases, and stroke. It is also associated with the disease progression. Therefore, it is critical to develop an effective strategy to target the hypoxic region for diagnosis and treatment.Author: Jicheng Yu, Yuqi Zhang, Xiuli Hu, Grace Wright, Zhen Gu
https://pubs.acs.org/doi/abs/10.1021/ma021540e
Jul 04, 2003 · Efficient in Vitro siRNA Delivery and Intramuscular Gene Silencing Using PEG-Modified PAMAM Dendrimers. Molecular Pharmaceutics 2012, 9 (6) , 1812-1821. DOI: 10.1021/mp3001364. Min Fang, Jiahai Zhang, Qinglin Wu, Tongwen Xu, and Yiyun Cheng .Author: István J. Majoros, Balázs Keszler, Scott Woehler, Tricia Bull, James R. Baker
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