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http://www.ijper.org/sites/default/files/IJPER_44_2_1.pdf
Key words: Nanoparticles, Non-viral Vectors, Gene therapy, Transfection. The delivery of functional genes to target cells for achieving therapeutic effect is defined as gene therapy. Gene therapy being treatment or prevention of disease by gene transfer is being considered as a …
https://www.researchgate.net/publication/5633360_Nanoparticles_as_Nonviral_Gene_Delivery_Vectors
Nanoparticles as Nonviral Gene Delivery Vectors 1) Monovalent aliphatic lipids. 2) Multivalent aliphatic lipids.
https://www.researchgate.net/publication/286369138_Nanoparticles_as_Non-Viral_Gene_Delivery_Vectors
Request PDF Nanoparticles as Non-Viral Gene Delivery Vectors Gene therapy is being considered as a potential medical revolution. Initially, it was viewed as an approach for treating hereditary ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/
May 21, 2014 · Among the non-viral vectors, nanoparticles showed remarkable properties regarding gene delivery such as the ability to target the specific tissue or cells, protect target gene against nuclease degradation, improve DNA stability, and increase the transformation efficiency or safety.Author: Solmaz Maleki Dizaj, Samira Jafari, Ahmad Yari Khosroushahi
https://www.sciencedirect.com/science/article/pii/S0378517311008179
Nov 28, 2011 · In this study, HA/CS-plasmid nanoparticles were created as novel, non-viral gene delivery vectors targeted to osteoarthritis and other joint diseases. The size and zeta potential of HA/CS-plasmid nanoparticles were related to composition, and generally there was an increase in size and a decrease in the surface charge with increasing HA.Author: Hua-Ding Lu, Hui-Qing Zhao, Kun Wang, Lu-Lu Lv
https://www.sciencedirect.com/science/article/pii/S0010854518301127
Despite the potentially higher biosafety of non-viral vectors in gene delivery, the therapeutic effect of single-functional non-viral vectors is far from satisfactory. In order to manage the challenges associated with non-viral vectors, multifunctional nanoparticles have been introduced.Author: Guimiao Lin, Li Li, Nishtha Panwar, Jie Wang, Swee Chuan Tjin, Xiaomei Wang, Ken-Tye Yong
https://pubs.acs.org/doi/10.1021/ar200151m
Successful gene therapy is thus dependent on the development of an efficient delivery vector.Researchers have pursued two major vehicles for gene delivery: viral and nonviral (synthetic) vectors. Although viral vectors currently offer greater efficiency, nonviral vectors, which are typically based on cationic lipids or polymers, are preferred ...Author: Xia Guo, Leaf Huang
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do …Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
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