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https://onlinelibrary.wiley.com/doi/abs/10.1002/med.20140
Traditional techniques such as spray drying and grinding, and more recent advances in supercritical fluid extraction, precipitation, and solvent extraction have been employed to produce nanoparticle formulations for pulmonary delivery. Here, the benefits of nanoparticle formulations and current progress are compared in light of the practical ...Author: Mark M. Bailey, Cory J. Berkland
https://www.researchgate.net/publication/23426515_Nanoparticle_Formulations_in_Pulmonary_Drug_Delivery
Adequately designed and engineered polymeric particles can contribute to a desirable pulmonary drug delivery characterized by a sustained drug release, prolonged drug action, reduction in the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013600/
Apr 08, 2014 · The choice of the inhalation device in a specific patient population also plays a vital role in nanoparticle-mediated drug delivery systems for pulmonary application. The complex relationship between nanoparticle systems and various parameters to be considered during formulation development is illustrated in Figure 1.Author: Mukta Paranjpe, Christel C. Müller-Goymann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Although solid NPs may be used for drug targeting, when reaching the intended diseased site in the body the drug carried needs to be released. So, for drug delivery biodegradable nanoparticle formulations are needed as it is the intention to transport and release the drug in order to be effective.Author: Wim H De Jong, Paul Ja Borm
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Nanoparticle drug formulations offer many advantages over traditional aerosol powders and liquid pulmonary dose formulations. For example, the bioavailability of poorly water-soluble drugs can be greatly enhanced by the large surface area of drug nanoparticle formulations. The literature suggests many different formulation approaches for drugs ...
https://www.sciencedirect.com/science/article/pii/S0378517317306397
Innovative pMDI formulations of spray-dried nanoparticles for efficient pulmonary drug delivery. ... Pulmonary drug delivery attracts rapidly increasing attentions as a route for the administration of pharmaceutically active agents for the treatment of local and systemic diseases ... It was shown that all pMDI nanoparticle formulations, either ...Author: Hao-Ying Li, En-Yu Xu
https://www.cell.com/trends/biotechnology/pdf/S0167-7799(07)00270-3.pdf
Nanoparticle drug delivery to the lungs The pulmonary delivery of therapeutic nanoparticles has been explored for systemic and local applications of a variety of molecules (Table 1). Advantages of nanoparticle drug delivery For biotherapeutics such as insulin, delivery to the lungs is a non-invasive method for systemic exposure over intravenous ...
https://www.researchgate.net/publication/250483287_ChemInform_Abstract_Nanoparticle_Formulations_in_Pulmonary_Drug_Delivery
The development of clinically acceptable albumin-based nanoparticle formulations for use in pulmonary drug delivery has been hindered by concerns about the toxicity of nanomaterials in the lungs ...
https://www.nature.com/articles/aps201734
May 01, 2017 · This article systematically reviews the challenges and opportunities for the pulmonary delivery of nanoparticle formulations for the treatment of lung cancers. You have full access to …Author: Sharad Mangal, Wei Gao, Tonglei Li, Qi (Tony) Zhou
https://kuscholarworks.ku.edu/bitstream/handle/1808/4343/umi-ku-2697_1.pdf;sequence=1
Nanoparticle Agglomeration via Ionic Colloidal Destabilization as a Novel Approach to Dry Powder Formulations for Pulmonary Drug Delivery By Carl J. Plumley B.S. Vanderbilt University Nashville, TN Submitted to the graduate degree program in Chemical and Petroleum Engineering and the Faculty of the
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