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https://www.ncbi.nlm.nih.gov/pubmed/28760499
The first, inhibition of drug delivery to healthy non-cancer cells and the second, the direct conduction of drugs into tumor site. Nanoparticles (NPs) are the new identified tools by which we can deliver drugs into tumor cells with minimum drug leakage into normal cells. Conjugation of NPs with ligands of cancer specific tumor biomarkers is a potent therapeutic approach to treat cancer diseases with the high …Author: Behdokht Bahrami, Behdokht Bahrami, Mohammad Hojjat-Farsangi, Mohammad Hojjat-Farsangi, Hamed Mohamm...
https://www.sciencedirect.com/science/article/pii/S0165247817301761
It has been shown that conjugation of nanocarriers with molecules such as antibodies and their variable fragments, peptides, nucleic aptamers, vitamins, and carbohydrates can lead to effective targeted drug delivery to cancer cells and thereby cancer attenuation.Author: Behdokht Bahrami, Behdokht Bahrami, Mohammad Hojjat-Farsangi, Mohammad Hojjat-Farsangi, Hamed Mohamm...
https://www.crcpress.com/Nanoparticle-Drug-Delivery-Systems-for-Cancer-Treatment/Gali-Muhtasib-Chouaib/p/book/9789814800549
Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs.
https://www.annualreviews.org/doi/abs/10.1146/annurev-med-040210-162544
Nanomedicine, the application of nanotechnology to medicine, enabled the development of nanoparticle therapeutic carriers. These drug carriers are passively targeted to tumors through the enhanced permeability and retention effect, so they are ideally suited for the delivery of chemotherapeutics in cancer treatment.Author: Andrew Andrew Wang, Robert Langer, Omid C. Farokhzad
https://clincancerres.aacrjournals.org/content/14/5/1310
Mar 01, 2008 · To improve the biodistribution of cancer drugs, nanoparticles have been designed for optimal size and surface characteristics to increase their circulation time in the bloodstream. They are also able to carry their loaded active drugs to cancer cells by selectively using the unique pathophysiology of tumors,...Author: Kwangjae Cho, Kwangjae Cho, Xu Wang, Shuming Nie, Zhuo (Georgia) Chen, Dong M. Shin
https://www.sciencedirect.com/science/article/pii/B9780323328890000145
Gold nanoparticles are excellent carrier molecules for cancer drug delivery. They can be synthesized in wide range of size with diverse surface functionalities. Tunability in size and surface characteristics makes them promising candidates as drug delivery vehicles.Author: Parvathy R. Chandran, Reny Thankam Thomas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596176/
Site/cell-specific drug delivery is particularly crucial in nanoparticle drug-delivery systems and can be achieved through the functionalization of AuNPs with both tumor-targeting ligands and therapeutic molecules . In order to design AuNPs as drug-delivery vectors, all of the abovementioned barriers must be considered and many groups have done so by investigating the pharmocokinetics and different targeting strategies for various nanoparticle designs.Author: Erik C Dreaden, Lauren A Austin, Megan A Mackey, Mostafa A El-Sayed
https://www.cancer.gov/nano/cancer-nanotechnology/benefits
Nanoparticle or nano-drug delivery is hampered by tissue barriers before the drug can reach the tumor site. Tissue barriers for efficient transporting of nano-drugs to tumor sites include tumor stroma (e.g. biological barriers) and tumor endothelium barriers (e.g. functional barriers).
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