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https://www.researchgate.net/publication/303981044_Nanoparticle-Based_Medicines_A_Review_of_FDA-Approved_Materials_and_Clinical_Trials_to_Date
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date. ... Liposomal drug delivery has become a clinical staple and it is clear .
https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10003
56 rows · Mar 31, 2016 · A number of other novel delivery nanoparticle systems are in clinical trials for cancer therapeutics such as targeted and stimuli responsive nanoparticles systems. These targeting and stimuli‐responsive systems will be highlighted in the next sections. 4.3 Applications other than cancer, iron‐replacement, or imagingAuthor: Aaron C. Anselmo, Samir Mitragotri
https://www.ncbi.nlm.nih.gov/pubmed/27299311
In this review we provide an up to date snapshot of nanomedicines either currently approved by the US FDA, or in the FDA clinical trials process. We define nanomedicines as therapeutic or imaging agents which comprise a nanoparticle in order to control the biodistribution, enhance the efficacy, or otherwise reduce toxicity of a drug or biologic.Author: Daniel Bobo, Kye J. Robinson, Jiaul Islam, Jiaul Islam, Kristofer J. Thurecht, Simon R. Corrie, Simo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089948/
Clinical trials have demonstrated that nanoparticle-based therapies are effective treatments for a variety of cancers, and can reduce the side-effect profiles of chemotherapeutics. Nanoparticles are being used to deliver increasingly sophisticated cargoes including small molecules, nucleic acids, peptides, proteins, and combinations of these ...Author: Jonathan S. Rink, Michael P. Plebanek, Sushant Tripathy, C. Shad Thaxton
https://aiche.onlinelibrary.wiley.com/doi/pdf/10.1002/btm2.10003
approved indications and their use in active clinical trials. Finally, we will discuss many of the often overlooked biological, technological, and study design challenges that impact the clinical success of nanoparticle delivery systems. KEYWORDS clinic, translational medicine, clinical translation, clinical trials, drug delivery, nanomedicine,Author: Aaron C. Anselmo, Samir Mitragotri
https://clincancerres.aacrjournals.org/content/14/5/1310
Mar 01, 2008 · However, in clinical trials conducted thus far, such early antibody-drug conjugates have failed to show superiority as a targeted delivery tool for the treatment of cancer . One of the reasons for this is that the number of drug molecules that can be loaded on the antibody while preserving its immune recognition is limited.Author: Kwangjae Cho, Kwangjae Cho, Xu Wang, Shuming Nie, Zhuo (Georgia) Chen, Dong M. Shin
https://clinicaltrials.gov/ct2/show/NCT03566199
Jun 25, 2018 · Safety of repeated convection-enhanced delivery (CED) of MTX110 following standard of care focal radiotherapy will be reported by summarizing the incidence of adverse events by maximum intensity and relationship to study drug. Adverse events will be graded according to Common Terminology Criteria for Adverse Events (CTCAE) version 4.0
https://www.researchgate.net/publication/303981044_Nanoparticle-Based_Medicines_A_Review_of_FDA-Approved_Materials_and_Clinical_Trials_to_Date
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date. ... Liposomal drug delivery has become a clinical staple and it is clear .
https://www.mir.wustl.edu/nanoparticle
Woodard nano particle approved for clinical trials. A new imaging agent may light up dangerous plaque in arteries, and Mallinckrodt radiologist Pamela K. Woodard, MD, led the team that designed the nanoparticle researchers hope to use to identify patients at high risk of stroke.
http://news.mit.edu/2012/cancer-particle-0404
Apr 04, 2012 · Targeted nanoparticles show success in clinical trials. ... One of the challenges in developing effective drug-delivery nanoparticles, Langer says, is designing them so they can perform two critical functions: evading the body’s normal immune response and reaching their intended targets. ... and that nanoparticle treatment resulted in ...
https://www.sciencedirect.com/science/article/pii/B9780128136898000021
Drug delivery to the target is the process of drug accumulation at the target site and this method is not dependent on the route or method of administration of drug (Torchilin, 2000).The term nanoparticles refers to particles having a size of one to several hundred nanometers (European Science Foundation, 2005).On decreasing the size of nanoparticles, their macroscopic physical properties will ...Author: Deepti Sharma, Navneet Sharma, Mallika Pathak, Paban K. Agrawala, Mitra Basu, Himanshu Ojha
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