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https://www.sciencedirect.com/science/article/pii/S0142961207006230
Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons. ... The use of nanoparticles for targeted drug delivery is often facilitated by specific conjugation of functional targeting molecules to the nanoparticle surface. We compared ... likely a result of some neutravidin non-specific binding to the nanoparticle ...Author: Seth A. Townsend, Gilad D. Evrony, Frank X. Gu, Martin P. Schulz, Robert H. Brown, Robert Langer
https://www.sciencedirect.com/science/article/pii/S0142961214012319
Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells. ... M.E. DavisA nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 1. Synthesis and characterization. Bioconjug …Author: Craig S. Schneider, Jimena G. Perez, Emily Cheng, Clark Zhang, Panagiotis Mastorakos, Justin S Hanes...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279109/
In this study, we focused on minimizing the non-specific binding to the brain ECM in the design of a targeted brain tissue penetrating nanoparticle system, which then permitted selective tumor cell targeting through minimal off-target binding.Author: Craig S. Schneider, Jimena G. Perez, Emily Cheng, Clark Zhang, Panagiotis Mastorakos, Justin S Hanes...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878482/
Reducing Non-Specific Binding and Uptake of Nanoparticles and Improving Cell ... The resulting integrin α v β 3 targeting nanoparticle conjugates showed improved cancer cell ... contrast between cancer targeted RGD-IONPs and non-targeting IONPs is important to the development of cancer targeting nanoparticle imaging agents and drug delivery.Author: Hongwei Chen, Liya Wang, Julie Yeh, Xinying Wu, Xinying Wu, Zehong Cao, Yongqiang A. Wang, Minming Z...
https://www.nature.com/articles/s41467-018-06979-4
Oct 31, 2018 · a We introduce the protein corona shield (PCS) concept for an efficient target drug delivery system. Generally, nanoparticle drug carriers with a target ligand lose their targeting ability on ...Author: Jun Yong Oh, Han Sol Kim, L. Palanikumar, Eun Min Go, Batakrishna Jana, Soo Ah Park, Ho Young Kim, K...
https://www.nature.com/articles/s41467-017-01830-8
Nov 23, 2017 · At nanoparticle to T cell ratios greater than 3600:1, up to 90% of the T cell population were bound by CD8a-targeting nanoparticles, with very little non-specific binding observed by isotype ...Author: Daniela Schmid, Chun Gwon Park, Christina A. Hartl, Nikita Subedi, Adam N. Cartwright, Regina Bou Pu...
https://advances.sciencemag.org/content/6/3/eaax3931.full
Jan 01, 2020 · Development of effective tumor cell–targeted nanodrug formulations has been quite challenging, as many nanocarriers and targeting moieties exhibit nonspecific binding to cellular, extracellular, and intravascular components. We have developed a therapeutic nanoparticle formulation approach that balances cell surface receptor-specific binding affinity while maintaining minimal …Author: Jimena G. Dancy, Aniket S. Wadajkar, Nina P. Connolly, Rebeca Galisteo, Heather M. Ames, Sen Peng, N...
https://scienceblog.com/513707/nanoparticle-therapy-shows-promise-with-breast-cancer/
Jan 24, 2020 · “Many drug delivery carriers exhibit non-specific binding to healthy cells and tissues in addition to the diseased cells they are targeting, which often leads to unintended side effects or toxicities,” said study corresponding co-author Anthony Kim, PhD, associate professor of neurosurgery and pharmacology at UMSOM.
https://www.medschool.umaryland.edu/news/2020/New-Nanoparticle-Therapy-Appears-More-Effective-Than-Standard-Therapy-at-Treating-Aggressive-Breast-Cancer.html
“Many drug delivery carriers exhibit nonspecific binding to healthy cells and tissues in addition to the diseased cells they are targeting, which often leads to unintended side effects or toxicities,” said study corresponding co-author Anthony Kim, PhD, Associate Professor of Neurosurgery and Pharmacology at UMSOM. “This DART nanoparticle ...
https://www.researchgate.net/publication/43181540_Reducing_Non-Specific_Binding_and_Uptake_of_Nanoparticles_and_Improving_Cell_Targeting_with_an_Antifouling_PEO-b-PgMPS_Copolymer_Coating
Reducing Non-Specific Binding and Uptake of Nanoparticles and Improving Cell Targeting with an Antifouling PEO-b-PγMPS Copolymer Coating ... and showed low non-specific binding by macromolecules ...
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