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https://www.nature.com/articles/s41551-017-0137-2
Here, we demonstrate that a delivery vehicle composed of gold nanoparticles conjugated to DNA and complexed with cationic endosomal disruptive polymers can deliver Cas9 ribonucleoprotein and donor ...Author: Kunwoo Lee, Michael Conboy, Hyo Min Park, Fuguo Jiang, Hyun Jin Kim, Hyun Jin Kim, Mark A. Dewitt, V...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
Apr 28, 2017 · Delivery of DNA via non-viral vectors offers the prospect of avoiding the immune response, and can potentially also manage larger payloads. The recent developments in nanomaterials, materials science, and polymer engineering have marked a turning point in the understanding of nanoscale delivery.Author: Michael K. Riley, Wilfred Vermerris
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
Upon injection, DNA was rapidly degraded by enzymes and eliminated from plasma due to extensive uptake by the liver (Kawabata et al., 1995). Chemical modification and a proper delivery method can reduce uptake by RES and protect nucleic acids from degradation by ubiquitous nucleases, which increase stability and efficacy of gene therapy.Author: Yi Zhao, Leaf Huang
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/medicated-nanoparticle-for-gene-delivery
Nanoparticle surface features like particle shape and surface charge are having major roles in the gene delivery. To provide the site-specific delivery various properties like nature of polymer, particle size, solubility, biocompatibility, biodegradability and nanoparticle surface features are need to be considered.Author: Sakthivel Lakshmana Prabu, Timmadonu Narasimman KuppusamiSuriyaprakash, Rathinasabapathy Thirumuruga...
https://pubs.acs.org/doi/abs/10.1021/nl304287a
The safe, targeted and effective delivery of gene therapeutics remains a significant barrier to their broad clinical application. Here we develop a magnetic nucleic acid delivery system composed of iron oxide nanoparticles and cationic lipid-like materials termed lipidoids. Coated nanoparticles are capable of delivering DNA and siRNA to cells in culture. The mean hydrodynamic size of these ...Author: Shan Jiang, Ahmed A. Eltoukhy, Kevin T. Love, Robert Langer, Daniel Griffith Anderson
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)38877-3
May 01, 2009 · Stereotactic neurosurgery was used to unilaterally inject either the acetate or the trifluoroacetate DNA nanoparticle formulation into the murine striatum. Using an in vivo imaging system (IVIS), we assessed the level of luciferase gene activity on days 3 and 7 post-delivery of the DNA nanoparticles. Following IVIS collection on day 7, brain ...
https://www.sciencedirect.com/science/article/pii/B9780081005576000043
As the present chapter describes the nanoparticle-mediated delivery of DNA, it is beyond the scope of this chapter to include a discussion on all these polymers that have been employed for such applications (Levine et al., 2013, Lin et al., 2015, Park and Yeo, 2014, Vasir and Labhasetwar, 2006, Yi …Author: Manohar Mahato, Ashwani Kumar Sharma, Pradeep Kumar
https://pubs.acs.org/doi/10.1021/bi0203987
Oct 19, 2002 · However, membrane transport of DNA is an inefficient process, and the mechanism(s) by which this process occurs is not clear. Although viral vectors are effective in gene therapy, the immune response elicited by viral proteins poses a major problem. Therefore, several laboratories are involved in the development of nonviral DNA delivery vehicles.Author: Veena Vijayanathan, Thresia Thomas,§,‖ and, T. J. Thomas
https://www.pnas.org/content/113/48/13600
Nov 29, 2016 · DNA-mediated nanoparticle assembly is an emerging concept to design drug delivery vehicles that can modify their structure or function in response to the in vivo environment. However, better understanding of their interactions with different tissues and organs is …Author: Kyryl Zagorovsky, Leo Y. T. Chou, Warren C. W. Chan
https://phys.org/news/2016-12-nanoparticle-based-method-dna-vaccine-delivery.html
Dec 19, 2016 · DNA vaccines also show promise as a tool for taming cancer growth. Although Draz, Shafiee, and their colleagues began by applying their novel nanoparticle method to …
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