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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
The aims for nanoparticle entrapment of drugs are either enhanced delivery to, or uptake by, target cells and/or a reduction in the toxicity of the free drug to non-target organs. Both situations will result in an increase of therapeutic index, the margin between the doses resulting in a therapeutic efficacy (eg,...Author: Wim H De Jong, Paul Ja Borm
https://f1000research.com/articles/6-681
May 16, 2017 · Nanoparticle-based drug delivery systems as a drug-like modulator for therapy NDDSs have always been used as a vehicle to deliver therapeutic drugs or imaging agents. Their physicochemical characteristics are carefully optimized to meet the demand of delivery and targeting.Author: Yi-Feng Wang, Yi-Feng Wang, Lu Liu, Lu Liu, Xue Xue, Xing-Jie Liang, Xing-Jie Liang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559243/
Adenoviral (Ad) vectors are one of the most efficient methods for gene delivery in vivo for vaccine applications. However, as for viral vectors in general, Ad vector use has been limited due to its activation of unwanted cellular, humoral and innate immune responses.Author: Yogita Krishnamachari, Sean M. Geary, Caitlin D. Lemke, Aliasger K. Salem
https://pubs.acs.org/doi/full/10.1021/ar500217w
Conspectus“Smart” stimuli-responsive nanomaterials are becoming popular as targeted delivery systems because they allow the use of internal or external stimuli to achieve spatial or temporal control over the delivery process. Among the stimuli that have been used, light is of special interest because it is not only noninvasive but also controllable both spatially and temporally, thus ...Author: Akshaya Bansal, Yong Zhang
https://www.sciencedirect.com/science/article/abs/pii/S1734114012709015
Abstract. Controlled drug delivery systems (DDS) have several advantages compared to the traditional forms of drugs. A drug is transported to the place of action, hence, its influence on vital tissues and undesirable side effects can be minimized. Accumulation of therapeutic compounds in the target site increases and, consequently,...Author: Agnieszka Z. Wilczewska, Katarzyna Niemirowicz, Karolina H. Markiewicz, Halina Car
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