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https://www.nature.com/articles/nrmicro1840
May 01, 2008 · Over the past 5 years, the use of recombinant LAB for mucosal delivery of therapeutic and prophylactic compounds, as well as DNA vaccines, has increased substantially (Fig. 4). Despite much progress, gaps remain in our understanding of the full potential of recombinant LAB, and many questions remain unanswered (Box 3).Author: Jerry M. Wells, Annick Mercenier
https://www.researchgate.net/publication/5507339_Mucosal_delivery_of_therapeutic_and_prophylactic_molecules_using_lactic_acid_bacteria
Consequently, recombinant probiotics have been created for mucosal delivery of therapeutic and/or prophylactic molecules comprising DNA, peptides, single-chain variable fragments, cytokines,...
https://www.narcis.nl/publication/RecordID/oai%3Alibrary.wur.nl%3Awurpubs%2F380804
Subsequently, interleukins have been co-expressed with antigens in LAB to enhance the immune response that is raised against the antigen. LAB have also been used as a delivery system for a range of molecules that have different applications, including anti-infectives, therapies for allergic diseases and therapies for gastrointestinal diseases.Author: Jerry M. Wells, Annick Mercenier
http://library.wur.nl/WebQuery/wurpubs/380804
Mucosal delivery of therapeutic and prophylactic molecules using lactic acis bacteria: Author(s) Wells, J.; ... as delivery vehicles have focused mainly on the development of mucosal vaccines, with much effort being devoted to the generation of genetic tools for antigen expression in …Author: Jerry M. Wells, Annick Mercenier
http://core.ac.uk/display/29255894
Subsequently, interleukins have been co-expressed with antigens in LAB to enhance the immune response that is raised against the antigen. LAB have also been used as a delivery system for a range of molecules that have different applications, including anti-infectives, therapies for allergic diseases and therapies for gastrointestinal diseases.Author: J. Wells and A.M.E. Mercenier
https://core.ac.uk/display/90829571
Subsequently, interleukins have been co-expressed with antigens in LAB to enhance the immune response that is raised against the antigen. LAB have also been used as a delivery system for a range of molecules that have different applications, including anti-infectives, therapies for allergic diseases and therapies for gastrointestinal diseases.Author: J. Wells and A.M.E. Mercenier
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