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https://www.nature.com/articles/nrmicro1840
May 01, 2008 · Another advantage of using LAB as mucosal delivery vehicles is that they can be engineered to express multiple proteins and other molecules; for example, expression of the type 3 …Author: Jerry M. Wells, Annick Mercenier
https://www.researchgate.net/publication/5507339_Mucosal_delivery_of_therapeutic_and_prophylactic_molecules_using_lactic_acid_bacteria
Consequently, recombinant probiotics have been created for mucosal delivery of therapeutic and/or prophylactic molecules comprising DNA, peptides, single-chain variable fragments, cytokines ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942074/
Sep 24, 2010 · A mucosal delivery system for therapeutic or prophylactic molecules is needed to avoid degradation and promote uptake of the antigen in the gastrointestinal tract and stimulate adaptive immune responses, rather than the tolerogenic responses that are seen in studies done with feeding soluble antigens , . In this study we report a second mucosal ...Author: Beatriz del Rio, Jesus Lajara Fuente, Vera Neves, Raymond Dattwyler, Jos F.M.L. Seegers, Maria Gomes...
https://www.academia.edu/12532308/Mucosal_delivery_of_therapeutic_and_prophylactic_molecules_using_lactic_acid_bacteria
Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231930/
Moreover, direct delivery of the appropriate medical molecules to exert their effects at mucosal surfaces is a very efficient prophylactic and therapeutic strategy. Mucosal surfaces are the primary interaction sites between an organism and its environment and they thus represent the …Author: Luis G Bermúdez-Humarán, Pascale Kharrat, Jean-Marc Chatel, Philippe Langella
https://www.researchgate.net/publication/232092884_Targeted_mucosal_delivery_of_drugs_and_vaccines
Targeted and more efficient delivery of molecules for therapeutic and prophylactic applications is a priority for the pharmaceutical industry.
https://link.springer.com/article/10.1007%2Fs00253-016-7557-x
May 07, 2016 · Recombinant lactic acid bacteria (LAB), in particular lactococci and lactobacilli, have gained increasing interest as mucosal delivery vehicles in recent years. With the development of mucosal vaccines, studies on LAB expression systems have been mainly focused on the generation of genetic tools for antigen expression in different locations.Author: Miao Wang, Zeqian Gao, Yongguang Zhang, Li Pan
https://microbialcellfactories.biomedcentral.com/articles/10.1186/1475-2859-10-S1-S4
Aug 30, 2011 · The administration of therapeutic molecules via mucosal routes offers several important advantages over systemic delivery such as reduction of secondary effects, easy administration and the possibility to modulate both systemic and mucosal immune responses [].Moreover, direct delivery of the appropriate medical molecules to exert their effects at mucosal surfaces is a very efficient ...
https://library.wur.nl/WebQuery/wurpubs/380804
Subsequently, interleukins have been co-expressed with antigens in LAB to enhance the immune response that is raised against the antigen. LAB have also been used as a delivery system for a range of molecules that have different applications, including anti-infectives, therapies for allergic diseases and therapies for gastrointestinal diseases.Author: Jerry M. Wells, Annick Mercenier
https://academic.oup.com/femsle/article/344/1/1/552126
Jul 01, 2013 · In addition, mucosal delivery of therapeutic proteins for chronic diseases and mucosal infections could enhance their potency and specificity and most importantly reduce potential side effect of the classical systemic routes of administration. ... Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria.Author: Jean Guy LeBlanc, Camille Aubry, Naima G. Cortes-Perez, Alejandra de Moreno de LeBlanc, Nathalie Ver...
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