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https://clincancerres.aacrjournals.org/content/23/6/1373
Mar 15, 2017 · Over the past few decades, clinical and preclinical studies have clearly demonstrated the role of mucins in tumor development. It is well established that mucins form a barrier impeding drug access to target sites, leading to cancer chemoresistance. Recently gained knowledge regarding core enzyme synthesis has opened avenues to explore the possibility of disrupting mucin synthesis to …Author: Chinthalapally V. Rao, Naveena B. Janakiram, Altaf Mohammed
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/
Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which ...
https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.12342
Oct 27, 2014 · Mucus is thus a highly complex gel barrier to drug delivery. Current knowledge of mucus characteristics and barrier properties, as achieved by state‐of‐the‐art methodologies, is the topic of this MiniReview emphasizing the gastrointestinal mucus and an overall focus on oral drug delivery.Author: Marie Boegh, Hanne Mørck Nielsen
https://muep.mau.se/bitstream/handle/2043/5930/Olof%20Svensson%20Kappan.pdf?sequence=1
presents layer-by-layer assembly of mucin and oppositely charged biopolymers (papers I, II and III). The second part is devoted to the interactions between particles aimed for drug delivery and mucin-coated surfaces (papers IV and V). I have presented what I consider to be the most important and interesting ob-
https://www.ncbi.nlm.nih.gov/pubmed/28039261
Mar 15, 2017 · In this Molecular Pathways article, we briefly discuss the potential role of mucin synthesis in cancers, ways to improve drug delivery and disrupt mucin mesh to overcome chemoresistance by targeting mucin synthesis, and the unique opportunity to target the GCNT3 pathway for the prevention and treatment of cancers.Author: Chinthalapally V. Rao, Naveena B. Janakiram, Altaf Mohammed
https://www.sciencedirect.com/science/article/pii/S1742706115001348
To generate a mucin-based hydrogel suitable for drug delivery, we used mucin from bovine submaxillary glands (BSM) available commercially from Sigma–Aldrich. BSM was selected as the model mucin for its commercial availability and relatively low viscosity in liquid …Author: Connor V. Duffy, Laurent David, Thomas Crouzier, Thomas Crouzier
https://www.sciencedirect.com/science/article/pii/S0939641115002222
Mucin is the main solid component of mucus, responsible for most of its gel-like properties and structure. Mucin undergoes electrostatic, hydrophobic and hydrogen bonding interactions, and thus, the presence of any non-endogenous materials such as drug delivery nanoparticles will undergo a myriad of interactions if it is to traverse this barrier.Author: Peter Charles Griffiths, Beatrice Cattoz, Mervat Shafik Ibrahim, Josephine Chibuzor Anuonye
https://www.researchgate.net/publication/38085992_Local_Drug_Delivery
The presence and composition of the mucus blanket, mucociliary clearance, direct mucin-drug binding, and the permeability of pharmaceutical compounds will all impact drug delivery.
https://www.mdpi.com/1999-4923/12/2/168
Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates all mucosal tissues can compromise drugs from reaching the epithelial site, thus affecting their absorption and therapeutic effect. Therefore, the effect of the mucus layer on ...Author: Margherita Falavigna, Paul C. Stein, Gøril Eide Flaten, Massimiliano Pio di Cagno
https://www.researchgate.net/publication/221750117_Mucoadhesive_drug_delivery_system_An_overview
Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of ...
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