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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
Aptamer-conjugated, multifunctional liposomes have been fabricated to encapsulate and deliver cisplatin to breast cancer cells (MCF-7). . The cell membrane is basically a dynamic lipid bilayer; therefore, this liposome nanostructure can efficiently increase cell permeability and enhance drug delivery.Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://tan.chem.ufl.edu/wp-content/uploads/sites/39/pubs/important-articles/Molecular%20aptamers%20for%20drug%20delivery.pdf
Molecular aptamers for drug delivery Weihong 3 Tan1,2, Hui Wang2, Yan Chen1,2,3, Xiaobing Zhang1, Haizhen Zhu1, Chaoyong Yang , Ronghua Yang1 and Chen Liu2 1State Key Laboratory ofChemo/Biosensing andChemometrics, CollegeBiology, Chemistry Chemical
https://www.sciencedirect.com/science/article/pii/S0167779911001132
When combined with the large number of recently created DNA aptamers that specifically target a wide variety of cancer cells, this drug–aptamer conjugation method has broad implications for targeted drug delivery. Aptamer-mediated cell type-specific small interfering RNA (siRNA) deliveryAuthor: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992821/
Mar 23, 2009 · To further prove that the linkage with aptamer can be useful for targeted drug delivery, we tested the cytotoxicity of our sgc8c-Dox conjugates with two more cell lines, NB-4 and Ramos cells (Figure 5). For CCRF-CEM, NB-4 and Ramos cells, the IC 50 of free Dox is about 0.32 ± 0.03 μM, 0.49 ± 0.07 μM and 1.46 ± 0.22 μM, respectively.Author: Yu Fen Huang, Dihua Shangguan, Haipeng Liu, Joseph A. Phillips, Xiaoling Zhang, Xiaoling Zhang, Yan ...
https://www.sciencedirect.com/science/article/pii/S2162253118301306
Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer. ... 5 In addition, gemcitabine has low molecular weight and high hydrophilicity and is easily degraded by cytidine deaminase, leading to poor cellular penetration.6, 7 To enhance the …Author: Jun Young Park, Ye Lim Cho, Ju Ri Chae, Sung Hwan Moon, Won Gil Cho, Yun Jung Choi, Soo Jin Lee, Won...
https://www.researchgate.net/publication/51551790_Molecular_aptamers_for_drug_delivery
Combined with aptamers, nanostructures are smart veicles with remarkable properties for drug delivery. Combination of aptamer and nanotechnology has resulted in the production of various targeted ...
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(11)00113-2
Dec 01, 2011 · In this review, we highlight the recent progress in aptamer-mediated delivery for therapeutics and disease-targeting based on aptamer integration with a variety of nanomaterials, such as gold nanorods, DNA micelles, DNA hydrogels and carbon nanotubes. ... Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells.Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://pubs.acs.org/doi/10.1021/mp300686g
Over recent years, cell surface nucleolin as an anticancer target has attracted many researchers’ attentions. To improve the antitumor efficacy, we developed a nucleolin targeted protein nanoparticle (NTPN) delivery system in which human serum albumin (HSA) was used as drug carrier and a DNA aptamer named AS1411, which had high affinity to nucleolin, was used as a bullet. The HSA ...Author: Jinhui Wu, Chenchen Song, Chenxiao Jiang, Xin Shen, Qian Qiao, Yiqiao Hu
https://pubs.acs.org/doi/pdf/10.1021/ja4117395
Automated Modular Synthesis of Aptamer−Drug Conjugates for Targeted Drug Delivery RuoWen Wang,† Guizhi Zhu,† Lei Mei,† Yan Xie,† Haibin Ma,† Mao Ye,† Feng-Ling Qing,§ and Weihong Tan*,† †Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative ...
http://cancerres.aacrjournals.org/content/78/3/798
Feb 01, 2018 · Extracellular nanovesicles (ENV) released by many cells contain lipids, proteins, and nucleic acids that contribute to intercellular communication. ENVs have emerged as biomarkers and therapeutic targets but they have also been explored as drug delivery vehicles. However, for the latter application, clinical translation has been limited by low yield and inadequate targeting effects. ENV ...Author: Yuan Wan, Lixue Wang, Lixue Wang, Chuandong Zhu, Qin Zheng, Guoxiang Wang, Jinlong Tong, Yuan Fang, ...
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