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https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(17)30190-7
In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are some of the most important biopharmaceuticals that are in commercial space as future medicines. This review summarizes the patents of miRNA- and siRNA-based new drugs, and also provides a snapshot about significant biopharmaceutical companies that are investing for the therapeutic development of miRNA …Author: Chiranjib Chakraborty, Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma, C. George Priya D...
https://link.springer.com/article/10.1007/s40820-019-0310-0
Sep 25, 2019 · Nanosized cytotoxic drug could combat against the autophagy induced by the drug. The drug nanorods enabled efficient intracellular delivery of the nucleic acid and the resultant autophagy inhibition in vitro and in vivo, which in turn sensitized the cancer cells to the anti-tumor nanorods. Nanosized cytotoxic drug could combat against the autophagy induced by the drug. The drug …Author: Xiaofei Xin, Xiaoqing Du, Qingqing Xiao, Helena S. Azevedo, Wei He, Lifang Yin
https://www.nature.com/articles/nrd.2016.246
Feb 17, 2017 · Trang, P. et al. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol. Ther. 19 , 1116–1122 (2011).Author: Rajesha Rupaimoole, Frank J. Slack
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · The limited separation of miRNA from the carrier has forced increased dose of miRNA to be active. Many current systems are focusing on using targeted drug delivery strategies to increase the amount of the drug that reaches the site, but targeting has a limited effect at increasing the total amount of drug that reaches the target organ .Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840794/
However, various critical prerequisite data must be available, for example, identification of signature miRNAs, their mechanism of action, applicability by RNAi, delivery of miRNAs, and their active form in vivo. Once this information is available, miRNA will have a bright future and become a …
https://www.sciencedirect.com/science/article/pii/S0168365913008031
The limited separation of miRNA from the carrier has forced increased dose of miRNA to be active. Many current systems are focusing on using targeted drug delivery strategies to increase the amount of the drug that reaches the site, but targeting has a limited effect at increasing the total amount of drug that reaches the target organ .Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://scholars.houstonmethodist.org/en/publications/microrna-and-drug-delivery(959f2844-e282-4309-b439-539e26956031).html
/ MicroRNA and drug delivery. MicroRNA in Development and in the Progression of Cancer. MicroRNA in Development and in the Progression of Cancer. Springer New York, 2014. pp. 359-403Author: Joseph S. Fernandez-Moure, Jeffrey Van Eps, Bradley K. Weiner, Mauro Ferrari, Ennio Tasciotti
https://www.sciencedirect.com/science/article/pii/S1818087614000646
The attitude of big pharmaceutical companies to RNAi drugs has also become over-optimistic. In summary, a good delivery system is the key to siRNA drug development. Once research into siRNA drug delivery systems makes a significant breakthrough, siRNA will occupy a strong position in the drug market, especially the anti-cancer drug market.Author: Cong-fei Xu, Jun Wang
http://zon.trilinkbiotech.com/2016/12/20/nanobombs-microrna/
Dec 20, 2016 · Therefore, the present study demonstrates the great potential of the NIR laser-activated “nanobomb” for microRNA delivery to achieve augmented cancer therapy.” Time will tell what aspects of this approach will ultimately be reduced to practice in the clinic and/or lead to an approved photodynamic therapy for cancer.
https://link.springer.com/chapter/10.1007/978-1-4899-8065-6_19
Abstract. The human genome was once thought to be a redundant sequence containing few functional regions coding for proteins. This teaching is being rewritten as we continue to understand the vast complexity of the noncoding regions of the genetic code.Author: Joseph S. Fernandez-Moure, Jeffrey Van Eps, Bradley K. Weiner, Mauro Ferrari, Ennio Tasciotti
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