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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · Currently, there are several commercially available lipid-based delivery systems (Table 2) and most investigations validating miRNA targets in vitro have used such systems. In recent years, significant effort has been dedicated to modifying the composition and chemical structure of liposomes, and some success has been achieved in delivering ...Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674998/
Viral and nonviral miRNA delivery systems have both advantages and disadvantages: Viral vectors produce higher transfection efficiency but are more toxic and immunogenic, whereas nonviral carriers have lower delivery efficiency but are much safer. Therefore, effective and safe miRNA delivery systems are in urgent need.
https://www.hindawi.com/journals/ije/2019/6782653/
Thus, this review summarizes the current attempts and existing deficiencies of chemical modifications and delivery systems applied in microRNA-based therapies for osteoporosis and osteoporotic fractures to inform further explorations. Emerging evidence demonstrates that microRNAs, as important endogenous posttranscriptional regulators, are ...Author: Xi Sun, Qi Guo, Wenhua Wei, Stephen Robertson, Ying Yuan, Xianghang Luo
https://www.sciencedirect.com/science/article/pii/S0168365913008031
Currently, there are several commercially available lipid-based delivery systems and most investigations validating miRNA targets in vitro have used such systems. In recent years, significant effort has been dedicated to modifying the composition and chemical structure of liposomes, and some success has been achieved in delivering siRNAs [85] .Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://www.researchgate.net/publication/334972559_Recent_progress_in_microRNA-based_delivery_systems_for_the_treatment_of_human_disease
Recent progress in microRNA-based delivery systems for the treatment of human disease Article (PDF Available) · December 2019 with 95 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S0734975017300204
To overcome these hurdles, diverse strategies and delivery systems are currently being studied. Traditionally, delivery systems for nucleic acids are classified as viral and non-viral vectors, but this review will be limited to non-viral vectors for miRNA therapy with …Author: I. Fernandez-Piñeiro, I. Badiola, A. Sanchez
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201801118?af=R
Apr 30, 2018 · Mesoporous silica nanoparticles (MSN) can load and deliver potentially synergistic anticancer agents such as small molecule cytotoxics (like doxorubicin, DOX) and nucleic acids (like microRNA, miRNA). However, these cargos have different underlying chemical properties so overcoming respective intracellular delivery barriers is a key consideration.Author: Hai‐Jun Liu, Xin Luan, Hai‐Yi Feng, Xiao Dong, Si‐Cong Yang, Zhong‐Jian Chen, Qin‐Yi Cai, Qin Lu, Yu...
https://www.mdpi.com/1420-3049/23/7/1500/pdf
molecules Review MicroRNA-Regulated Gene Delivery Systems for Research and Therapeutic Purposes Bijay Dhungel 1,2,3 ID, Charmaine A. Ramlogan-Steel 2,4 and Jason C. Steel 2,5,* 1 Gallipoli Medical Research Institute, Greenslopes Private Hospital, 102 Newdegate Street, Brisbane, QLD 4120, Australia; [email protected]: Bijay Dhungel, Charmaine A. Ramlogan-Steel, Jason C. Steel
https://www.mdpi.com/1420-3049/23/7/1500/htm
MicroRNA-Regulated Gene Delivery Systems for Research and Therapeutic Purposes . by Bijay Dhungel 1,2,3, Charmaine A. Ramlogan-Steel 2,4 and Jason C. Steel 2,5,* 1. Gallipoli Medical Research Institute, Greenslopes Private Hospital, 102 Newdegate Street, Brisbane, QLD 4120, Australia. 2.Author: Bijay Dhungel, Charmaine A. Ramlogan-Steel, Jason C. Steel
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(17)30190-7
Diverse miRNA and siRNA molecule carriers have been suggested and developed differently that may have better stabilities and efficiencies with therapeutic RNA delivery systems. However, pharmaceutical companies need to apply these delivery systems to promote more efficient delivery of commercial therapeutic RNAs.Author: Chiranjib Chakraborty, Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma, C. George Priya D...
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