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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
This review will focus on current challenges and strategies for delivery of miRNAs In vivo through local and systemic or targeted administration. The strategies employed in In vivo miRNA delivery for cancer therapy are summarized in Table 1.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.ncbi.nlm.nih.gov/pubmed/29086376
MicroRNA-7 (miR-7) is a tumor suppressor miRNA that has been shown to target oncogenes overexpressed in cancers, such as the epidermal growth factor receptor (EGFR) and the nuclear factor-κ B subunit, RelA. Here, we describe methods for evaluating systemic delivery of miR-7 using a lipid nanoparticle formulation in an animal model.Author: Rikki A. M. Brown, Kirsty L. Richardson, Felicity C. Kalinowski, Michael R. Epis, Jessica L. Horsham...
https://www.sciencedirect.com/science/article/pii/S0169409X14001033
This review will focus on current challenges and strategies for delivery of miRNAs in vivo through local and systemic or targeted administration. The strategies employed in in vivo miRNA delivery for cancer therapy are summarized in Table 1.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201911712
Jan 21, 2020 · Herein, an autocatalytic DNAzyme (ACD) biocircuit is constructed for amplified microRNA imaging in vivo based on a hybridization chain reaction (HCR) and DNAzyme biocatalysis, sustained by a honeycomb MnO 2 nanosponge (hMNS).Author: Jie Wei, Huimin Wang, Qiong Wu, Xue Gong, Kang Ma, Xiaoqing Liu, Fuan Wang
https://www.sciencedirect.com/science/article/pii/S1525001617301648
In this report, we demonstrate an effective microRNA delivery system in the form of NCPs carrying oligometastases-associated 14q32-encoded miR-655-3p in an experimental model of colorectal hepatic metastases that was quantifiable through in vivo bioluminescence and ex vivo fluorescence. 8 Our results suggest that an NCP-based microRNA delivery ...Author: Go Oshima, Nining Guo, Chunbai He, Melinda E. Stack, Christopher Poon, Abhineet Uppal, Sean C. Wight...
https://www.hindawi.com/journals/ije/2019/6782653/
Despite the fact that RVs have been widely utilized in life sciences research over several decades, there are few studies about in vivo microRNA delivery for treating osteoporosis or osteoporotic fracture by RVs. The inability of transducing nondividing cells and the dysfunction of host cells caused by genome integration at an undesired ...Author: Xi Sun, Qi Guo, Wenhua Wei, Stephen Robertson, Ying Yuan, Xianghang Luo
https://link.springer.com/article/10.1007/s40820-019-0310-0
Sep 25, 2019 · Nanosized cytotoxic drug could combat against the autophagy induced by the drug. The drug nanorods enabled efficient intracellular delivery of the nucleic acid and the resultant autophagy inhibition in vitro and in vivo, which in turn sensitized the cancer cells to the anti-tumor nanorods. Nanosized cytotoxic drug could combat against the autophagy induced by the drug. The drug …Author: Xiaofei Xin, Xiaoqing Du, Qingqing Xiao, Helena S. Azevedo, Wei He, Lifang Yin
http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
https://www.researchgate.net/publication/320737499_Evaluation_of_MicroRNA_Delivery_In_Vivo
Evaluation of MicroRNA Delivery In Vivo. ... Major hurdles lie in the development of chemical modifications and delivery systems for in vivo delivery. Nevertheless, advancement in miRNA ...
https://www.nature.com/articles/ncomms12868
Sep 19, 2016 · In vivo delivery of miR-96 or miR-182 carried on nanoparticles which are embedded in a hydrogel scaffold patch and implanted adjacent to the tumour, …Author: Avital Gilam, João Conde, João Conde, Daphna Weissglas-Volkov, Nuria Oliva, Eitan Friedman, Natalie ...
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