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https://www.sciencedirect.com/science/article/pii/S1773224715000714
Microneedles have been widely studied for transdermal delivery of insulin. In this review, we describe the recent and emerging progress in MN technologies for insulin delivery, which suggest that MNs may provide a powerful new approach for transdermal insulin delivery.Author: Song Xie, Zijing Li, Zongqin Yu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444834/
Jan 08, 2018 · Microneedle for Insulin Delivery. Although noninvasive glucose monitoring has greatly modified, the techniques used still lag many complications due to the devices that rely basically on the inexact mathematical algorithms. Traditional methods, on the hand, employ hypodermic needles which have been found to highly undesirably painful and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164338/
Sep 05, 2018 · 3.4. In Vivo Study of Transdermal Delivery of FITC-Insulin from MNs. In order to characterize the skin permeation of FITC-insulin from loaded MNs, patches with and without insulin were applied to mice for 10 min before removal. Using the IVIS, images were …Author: Chih-Hao Chen, Victor Bong-Hang Shyu, Chien-Tzung Chen
https://pubs.acs.org/doi/abs/10.1021/acsnano.7b08152
A bioinspired glucose-responsive insulin delivery system for self-regulation of blood glucose levels is desirable for improving health and quality of life outcomes for patients with type 1 and advanced type 2 diabetes. Here we describe a painless core–shell microneedle array patch consisting of degradable cross-linked gel for smart insulin delivery with rapid responsiveness and excellent ...Author: Jinqiang Wang, Yanqi Ye, Jicheng Yu, Anna R. Kahkoska, Xudong Zhang, Chao Wang, Wujin Sun, Ria D. Co...
https://www.nature.com/articles/s41591-019-0598-9
Using insulin as a model drug, we showed that, when actuated, the luminal unfolding microneedle injector provided a faster pharmacokinetic uptake profile and a systemic uptake >10% of that of a ...Author: Alex Abramson, Ester Caffarel-Salvador, Vance Soares, Daniel Minahan, Ryan Yu Tian, Xiaoya Lu, David...
https://www.sciencedirect.com/science/article/pii/S0169409X18300504
Usually, insulin is administrated by subcutaneous (SC) injection using various processes such as syringe, insulin pen and pump [].The SC injection remains the advantages including low cost, high absorption ability and delivery efficiency of drugs, thereby, widely used in drug delivery.Author: Xuan Jin, Dan Dan Zhu, Bo Zhi Chen, Mohammad Ashfaq, Xin Dong Guo
https://news.harvard.edu/gazette/story/2019/02/microneedle-pill-takes-the-sting-out-of-insulin/
Approximately the size of a pea, the SOMA houses a needle made of insulin and its injection is controlled by a spring held in place by a sugar disc. The sugar disc allows the humidity in the stomach to serve as the trigger of the micro-injection, and the solid insulin needle enables delivery of …
https://clinicaltrials.gov/ct2/show/NCT00837512
Norman JJ, Brown MR, Raviele NA, Prausnitz MR, Felner EI. Faster pharmacokinetics and increased patient acceptance of intradermal insulin delivery using a single hollow microneedle in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2013 Sep;14(6):459-65. doi: 10.1111/pedi.12031. Epub 2013 Mar 21.
https://www.pnas.org/content/112/27/8260
Jul 07, 2015 · For exploiting synthetic glucose-responsive insulin delivery systems, challenges remain to demonstrate a strategy that would combine ( i ) fast responsiveness, ( ii ) ease of administration, and ( iii ) excellent biocompatibility. We have developed a novel glucose-responsive insulin delivery device using a painless microneedle-array patch containing hypoxia-sensitive hyaluronic acid-based ...Author: Jicheng Yu, Yuqi Zhang, Yanqi Ye, Rocco DiSanto, Wujin Sun, Davis Ranson, Frances S. Ligler, John B....
http://drugdelivery.chbe.gatech.edu/Papers/2009/Gupta%20Diabetes%20Technol%20Ther%202009.pdf
Minimally Invasive Insulin Delivery in Subjects with Type 1 Diabetes Using Hollow Microneedles Jyoti Gupta, B.S.,1,2 Eric I. Felner, M.D.,1,2 and Mark R. Prausnitz, Ph.D.1,3 Abstract Background: Microneedles have previously been used to deliver insulin to animal models, but not in human
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