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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627464/
Dec 05, 2012 · Microneedle arrays (MN) are minimally-invasive devices that painlessly by-pass the skin's stratum corneum, which is the principal barrier to topically-applied drugs. 1 MN (50–900 μm in height, up to 2000 MN cm −2) have been extensively investigated in recent years as a means to enhance transdermal drug and vaccine delivery. 2 – 10 No MN ...Author: Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska, Rita Majithiya, Cia...
https://www.sciencedirect.com/science/article/pii/S0169409X03002394
Since the first studies of transdermal drug delivery in 1998 , there has been rapidly increasing interest in the field, with most activity in the microfabrication community to develop novel needle fabrication technologies and the drug delivery industry to develop microneedles for pharmaceutical applications. 2.Author: Mark R Prausnitz
https://www.sciencedirect.com/science/article/pii/S1471489217300826
Microneedle mediated delivery based research has garnered great interest in recent years. In the past, the initial focus was delivery of macromolecules of biological origin, however the field has now broadened its scope to include transdermal delivery of conventional low molecular weight drug molecules.Author: Kurtis Moffatt, Yujing Wang, Thakur Raghu Raj Singh, Ryan F Donnelly
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724014/
The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable of encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, the elastic properties ...Author: Seunghee Lee, Shayan Fakhraei Lahiji, Jeesu Jang, Mingyu Jang, Hyungil Jung
https://www.researchgate.net/publication/318917313_Microneedles_for_enhanced_transdermal_and_intraocular_drug_delivery
Microneedle-based transdermal and ocular drug delivery systems have the potential to greatly impact not only patient benefits, but also industry, and through diligence, innovation and ...
https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.201200864
and transdermal drug delivery is now controlled by the crosslink density of the hydrogel system rather than the stratum corneum, while electrically modulated delivery is also a unique feature. Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery Unique microneedle arrays prepared from crosslinked polymers, which con-Author: Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska, Rita Majithiya, Cia...
https://www.mdpi.com/1999-4923/11/8/402
The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable of encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, the elastic properties of the skin prevent DMNs from complete insertion and accurate delivery of encapsulated compounds into the skin. Moreover, the adhesive ...Author: Seunghee Lee, Shayan Fakhraei Lahiji, Jeesu Jang, Mingyu Jang, Hyungil Jung
https://www.nature.com/articles/s41598-020-58822-w
Feb 06, 2020 · Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches. ... Transdermal drug delivery system …Author: Moonjeong Bok, Zhi-Jun Zhao, Sohee Jeon, Jun-Ho Jeong, Eunju Lim
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
Microneedle application is an emerging technique for transdermal drug delivery and this is reflected by the large number of patent applications filed. 125-133 The majority of these patent applications are focused around design of, and delivery through, hollow microneedles since a higher amount of drug can be delivered from such microneedles as ...Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
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