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https://www.3m.com/3M/en_US/drug-delivery-systems-us/technologies/microneedle/
3M Microneedle Drug Delivery Systems, which include Hollow Microneedle and Solid Microneedle technology, offer patient-friendly delivery solutions for vaccines or difficult-to-deliver biologics for particularly needle-phobic patients. By potentially reducing anxiety, microneedle delivery may improve patient compliance in some patient groups.
https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1471059
Dec 23, 2014 · 1. Microneedle patches for drug delivery to skin. Drug delivery is often limited by the need to cross a barrier to gain access to target tissues. In the case of skin, the main barrier is the skin’s outer layer of stratum corneum, which measures just 10–20 µm in thickness, but effectively blocks delivery of most molecules into the body .Author: Jeong Woo Lee, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419303/
The use of a microneedle patch, either coated with or encapsulating drugs, is arguably the simplest method of microneedle-based drug delivery for patients. In this scenario, the patient applies the patch to the skin, possibly using an applicator, and then leaves the patch in place probably for a few minutes before discarding it.Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.annualreviews.org/doi/abs/10.1146/annurev-chembioeng-060816-101514
Microneedle patches (MNPs) contain arrays of solid needles measuring hundreds of microns in length that deliver drugs and vaccines into skin in a painless, easy-to-use manner. Optimal MNP design balances multiple interdependent parameters that determine mechanical strength, skin-insertion reliability, drug delivery efficiency, painlessness, manufacturability, and other features of MNPs that ...Author: Mark R. Prausnitz
https://www.ondrugdelivery.com/teriparatide-micro-patch-solid-microneedle-product-nearing-clinical-trials/
Nemaura focuses on drug delivery through the skin and, in addition to its Micro-Patch microneedle solid dose delivery system, has programmes involving topical gels, transdermal patches, simple injectable drugs for SC, IM and ID delivery using liquid micro-injectors, and complex injectables.
https://www.nature.com/articles/s41591-019-0606-0
Oct 07, 2019 · A novel oral capsule can deploy microneedle patches that release drugs into the intestinal wall for uptake into the bloodstream as shown in animal studies, thereby avoiding injections.Author: Mark R. Prausnitz, Yasmine Gomaa, Yasmine Gomaa, Wei Li
https://www.ncbi.nlm.nih.gov/pubmed/28552053
As a drug delivery tool, microneedle patches can deliver bioactive molecular of different physical size. Additionally, microneedle patches can be coated or encapsulate with DNA vaccine, subunit antigen, inactivated or live virus vaccine.Author: Junwei Li, Mingtao Zeng, Hu Shan, Chunyi Tong
https://www.researchgate.net/publication/336337486_Microneedle_patch_drug_delivery_in_the_gut
Microneedle patch drug delivery in the gut. ... Recently developed for drug delivery, the new microneedle apparatus has the potential to improve this efficiency. In this study, ...
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201905740
However, their efficacy has been limited by slow diffusion of molecules and often requires external triggers. Herein, an autonomous and degradable, active microneedle delivery platform is introduced, employing magnesium microparticles loaded within the microneedle patch, as the built‐in engine for deeper and faster intradermal payload delivery.Author: Miguel Angel Lopez‐Ramirez, Fernando Soto, Chao Wang, Ricardo Rueda, Sourabh Shukla, Cristian Silva‐...
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