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https://www.sciencedirect.com/science/article/pii/S0022354915506242
Research Articles Microfabricated Microneedles: A Novel Approach to Transdermal Drug Delivery Sebastien Henry, †‡ Devin V. McAllister, †§ Mark G. Allen, * ∥ [email protected] Mark R. Prausnitz, * ‡ § [email protected] Institute for Bioengineering and Bioscience, School of Chemical Engineering, School of Electrical and Computer Engineering, and School of ...Author: Sebastien Henry, Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/pii/S0169409X03002394
2. Transdermal drug delivery using microneedles. The overarching motivation for microneedles is that they can provide a minimally invasive means to transport molecules into the skin. Guided by this goal, a number of specific strategies have been employed to use microneedles for transdermal delivery.Author: Mark R Prausnitz
http://drugdelivery.chbe.gatech.edu/Papers/1998/Henry%20J%20Pharm%20Sci%201998.pdf
Microfabricated Microneedles: A Novel Approach to Transdermal Drug Delivery SEBASTIEN HENRY,†,‡ DEVIN V. MCALLISTER,‡,§ MARK G. ALLEN,*, AND MARK R. PRAUSNITZ*,‡,§ Contribution from Institute for Bioengineering and Bioscience, School of Chemical Engineering, School of Electrical and Computer Engineering, and School of Mechanical Engineering, Georgia Institute of …
http://drugdelivery.chbe.gatech.edu/Papers/2003/Prausnitz%20Microfabricated%20Microneedles%20in%20Modified%20Release%20Drug%20Del%20Sys%202003.pdf
Microfabricated Microneedles for Transdermal Drug_ Delivery Mark R. Prausnitz Georgia Institute of Technology, Atlanta, Georgia, U.S.A. Donald E. Ackley* and J. Richard Gyoryt Redeon, Inc., Burlington, Massachusetts, U.S.A. I. INTRODUCTION Drug delivery technologies strive to balance the ability to deliver drugs effec
https://onlinelibrary.wiley.com/doi/abs/10.1021/js980042%2B
Jun 12, 2000 · Microfabricated microneedles: A novel approach to transdermal drug delivery ... (e.g., pills and injections). Transdermal delivery is an attractive alternative, but it is limited by the extremely low permeability of skin. ... This paper describes the first published study on the use of microfabricated microneedles to enhance drug delivery ...Author: Sebastien Henry, Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906704/
Many promising therapeutic agents are limited by their inability to reach the systemic circulation, due to the excellent barrier properties of biological membranes, such as the stratum corneum (SC) of the skin or the sclera/cornea of the eye and others.The outermost layer of the skin, the SC, is the principal barrier to topically-applied medications.Author: Ryan F. Donnelly, Thakur Raghu Raj Singh, A. David Woolfson
https://journals.lww.com/anesthesia-analgesia/pages/articleviewer.aspx?year=2001&issue=02000&article=00041&type=Fulltext
As a novel alternative, we have used microfabrication technology to make microneedles that pierce into the skin far enough to permit drug delivery, but are short and thin enough to avoid causing pain. The skin’s stratum corneum provides the greatest barrier to drug transport into the body . Because this layer contains no nerves, a microneedle ...
https://www.annualreviews.org/doi/10.1146/annurev.bioeng.2.1.289
Finally, microhypodermic needles and microneedles for transdermal drug delivery have been developed to reduce needle insertion pain and tissue trauma and to provide controlled delivery across the skin. These needles have been shown to be robust enough to penetrate skin and dramatically increase skin permeability to macromolecules.Author: Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · Transdermal drug delivery offers a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered …Author: Kevin B. Ita
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