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https://www.annualreviews.org/doi/10.1146/annurev.bioeng.2.1.289
Abstract By incorporating techniques adapted from the microelectronics industry, the field of microfabrication has allowed the creation of microneedles, which have the potential to improve existing biological-laboratory and medical devices and to enable novel devices for gene and drug delivery. Dense arrays of microneedles have been used to deliver DNA into cells.Author: Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://www.annualreviews.org/doi/abs/10.1146/annurev.bioeng.2.1.289
Abstract By incorporating techniques adapted from the microelectronics industry, the field of microfabrication has allowed the creation of microneedles, which have the potential to improve existing biological-laboratory and medical devices and to enable novel devices for gene and drug delivery. Dense arrays of microneedles have been used to deliver DNA into cells.Author: Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://www.researchgate.net/publication/313724980_Microfabricated_microneedles_for_gene_and_drug_delivery
In most cases, in-plane microneedles are fabricated with conventional silicon MEMS techniques and can be used for precise drug delivery to a target region or tissue of the body [1], whereas out-of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906704/
Hollow microneedles for suprachoroidal drug delivery to the posterior segment of the eye. Controlled Release Society. 2009 Jul 18–22; Pearton M, Allender C, Brain K, Anstey A, Gateley C, Wilke N, Anthony M, Birchall J. Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations.Author: Ryan F. Donnelly, Thakur Raghu Raj Singh, A. David Woolfson
https://www.sciencedirect.com/science/article/pii/S0022354915506242
Limited tests on human subjects indicated that microneedles were reported as painless. This paper describes the first published study on the use of microfabricated microneedles to enhance drug delivery across skin.Author: Sebastien Henry, Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2133.2004.05921.x
Grace Cole, Nicholas J. Dunne and Helen O. McCarthy, Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers, Microneedles for Drug and Vaccine Delivery and Patient Monitoring, (129-175), (2018).Author: F. Chabri, K. Bouris, T. Jones, David Anthony Barrow, Anthony Hann, C. Allender, K. Brain, J. Bircha...
http://drugdelivery.chbe.gatech.edu/Papers/1998/Henry%20J%20Pharm%20Sci%201998.pdf
of microfabricated microneedles to enhance drug delivery across skin. Introduction The development of more sophisticated drugs has de-manded the need for more sophisticated methods to deliver those drugs. Conventional drug delivery techniques using pills …
https://www.sciencedirect.com/science/article/pii/S0169409X03002394
Most drug delivery studies have emphasized solid microneedles, which have been shown to increase skin permeability to a broad range of molecules and nanoparticles in vitro. In vivo studies have demonstrated delivery of oligonucleotides, reduction of blood glucose level by insulin, and induction of immune responses from protein and DNA vaccines.Author: Mark R Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · Microneedles can be used to enhance transdermal drug delivery. In this review, different types of microneedles are described and their methods of fabrication highlighted. Microneedles can be fabricated in different forms: hollow, solid, and dissolving.Author: Kevin B. Ita
https://mentoriafabioborges.com.br/wp-content/uploads/2019/08/2009-SHIVANAND-MICROAGULHAMENTO-VARIAS-TECNICAS-DE-FABRICAÇÃO-E-AVALIAÇÕES.pdf
the skin, and complete the integration of microneedles into a full diagnostic, monitoring or drug delivery system. Microneedles are expected to be less painful than conventional hypodermic needles because they are too small to significantly stimulate nerve endings. A painless "microneedle" that mimics the way a female mosquito sucks blood has
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