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https://www.sciencedirect.com/science/article/pii/S0169409X00001137
2. Application of microdialysis in human drug studies 2.1. Antimicrobial agents. Studies on target tissue penetration of antibiotics are a critical part in clinical drug development and are mostly based on skin blister or biopsy studies, two techniques with considerable disadvantages , , , .Author: Markus Müller
https://www.sciencedirect.com/science/article/pii/S1569733906160336
II.A. Microdialysis in clinical drug delivery studies in humans: theoretical considerations II.A.1. In vivo probe calibration. Although different techniques have been developed for in vivo calibration of MD probes, the “equilibrium method” is considered the method of choice (Lönnroth et al., 1987). This technique, however, is time consuming and requires steady-state conditions, which are usually not …Author: Martin Brunner, Markus Müller
https://www.deepdyve.com/lp/elsevier/microdialysis-in-clinical-drug-delivery-studies-AU0cxrjWtm
Dec 15, 2000 · Microdialysis in clinical drug delivery studies Müller, Markus 2000-12-15 00:00:00 The introduction of in vivo microdialysis (MD) to clinical pharmacological studies has opened the opportunity to obtain previously inaccessible information about the drug distribution process to the clinically relevant target site. The aim of this review is to provide a comprehensive overview of the current literature about MD in drug delivery studies from a clinical …Author: Müller, Markus
https://www.researchgate.net/publication/251467879_Chapter_71_Microdialysis_in_clinical_drug_delivery_studies
The principle of microdialysis in drug delivery studies has been described in detail previ- ously [6]. Microdialysis is based on the sampling of analytes from the extracellular space by means of a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994531/
Drug delivery to brain cancer is inherently complex. Poor drug delivery to tumor contributes to the disappointing results of clinical trials in brain cancer. Microdialysis is a powerful research tool that enables serial sampling of drug levels in brain with simultaneous assessment of plasma PK.Author: Jaishri Blakeley, Jana Portnow
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