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https://www.sciencedirect.com/topics/materials-science/micelle
Micelles are used for targeted drug delivery due to their high drug loading capacity, and opsonization of these micelles with sugar or peptide can also result in receptor-mediated targeted drug or gene delivery. pH and temperature-sensitive copolymers are used to develop intelligent vehicles, which are currently being used for achieving controlled release (Mourya et al., 2011). Intermolecular interaction among the block polymers leads to the formation of micelles…
https://pubs.rsc.org/en/content/articlelanding/2020/py/d0py00082e
Hydrogen-bonded supramolecular micelle-mediated drug delivery enhances the efficacy and safety of cancer chemotherapy† Chih-Chia Cheng , * ab Ya-Ting Sun , a Ai-Wei Lee , cde Shan-You Huang , a Wen-Lu Fan , a Yu-Hsuan Chiao , f Chih-Wei Chiu g and Juin-Yih Lai abhiAuthor: Chih-Chia Cheng, Ya-Ting Sun, Ai-Wei Lee, Shan-You Huang, Wen-Lu Fan, Yu-Hsuan Chiao, Chih-Wei Chiu,...
http://www.authorstream.com/Presentation/Omarmarwa-1404778-micelle-drug-delivery/
Apr 30, 2012 · APPLICATIONS Micelle increases bioavailability of poorly soluble drugs. Polymeric micelle is used to target the tumor site by passive as well as active mechanism. Micelle is used in ophthalmic drug delivery system, that effectively delivers the drug to posterior tissue of eyeball. Micelle is used to encapsulate the antibiotic & anticancer drugs.
http://www.eurekaselect.com/58294/article
The polymeric micelles used for drug delivery in these examples have shown the abilities to attenuate toxicities, enhance delivery to desired biological sites and improve the therapeutic efficacy of active pharmaceutical ingredients.
https://www.hindawi.com/journals/jdd/2013/340315/
Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug from the harsh environment of the GI tract, (2) release of the drug in a controlled manner at target sites, (3) prolongation of the residence time in the gut by mucoadhesion, and (4) inhibition of efflux pumps to improve the drug …Author: Wei Xu, Peixue Ling, Tianmin Zhang
https://www.tandfonline.com/doi/abs/10.1080/10717544.2020.1748760
(2020). Preparation and antitumor evaluation of hinokiflavone hybrid micelles with mitochondria targeted for lung adenocarcinoma treatment. Drug Delivery: Vol. 27, No. 1, pp. 565-574.
https://www.ncbi.nlm.nih.gov/pubmed/17168771
The polymeric micelles used for drug delivery in these examples have shown the abilities to attenuate toxicities, enhance delivery to desired biological sites and improve the therapeutic efficacy of active pharmaceutical ingredients.Author: S. R. Croy, G. S. Kwon
https://micellebiopharma.com/about/
A patented drug delivery concept developed by Dr. Fred Sancilio Eliminates problems associated with absorption of fatty acids like DHA Uses micelles (microscopic molecular balloons) to substantially increase the bioavailability of fatty acids like DHA and other lipophilic compounds thus lending their use as potential APIs for treating a range of disease conditions.
https://www.unmc.edu/pharmacy/faculty/pharmaceutical-sciences/docs/v5.pdf
One of the first reported examples of unimolecular micelles suitable for drug delivery was a threearm star polymer - composed of mucic acid substituted with fatty acids as a lipophilic inner block and PEO as a hydrophilic outer block.
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