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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955097/
Sep 18, 2013 · We describe here the development of site-specific antibody-polymer conjugates (APCs) for the selective delivery of small interference RNAs (siRNAs) to target cells. APCs were synthesized in good yields by conjugating an aminooxy-derivatized cationic block ...Author: Hua Lu, Danling Wang, Stephanie Kazane, Tsotne Javahishvili, Feng Tian, Frank Song, Aaron Sellers, B...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333408/
Jan 30, 2015 · The first reports of antibody-mediated siRNA delivery focused narrowly on individual antibody–antigen interactions and only one or a few cell types. We aimed to study ARC-mediated delivery more broadly and to survey how a variety of properties …Author: Trinna L. Cuellar, Dwight Barnes, Christopher Nelson, Joshua Tanguay, Shang-Fan Yu, Xiaohui Wen, Suz...
http://www.nature.com/articles/nbt1101
May 22, 2005 · Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to deliver …Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-019-1804-8
Feb 22, 2019 · Antibodies are now used as frontline therapeutics in highly divergent indications, ranging from autoimmune disease over allergic asthma to cancer. Wider accessibility and implementation of antibody-based therapeutics is however hindered by manufacturing challenges and high development costs inherent to protein-based drugs.Author: Lien Van Hoecke, Kenny Roose
https://www.liebertpub.com/doi/10.1089/nat.2018.0726
Jun 01, 2018 · Messenger RNA is highly unstable in extracellular biological fluids due to the presence of nucleases, and an effective delivery vehicle must protect against potential digestion. The proliferation of nanoparticles for mRNA delivery is driven by such a requirement as opposed to the direct conjugates that currently dominate the antisense oligonucleotide (ASO) and siRNA oligonucleotide therapeutic …Author: Matthew G. Stanton
https://www.researchgate.net/publication/51485197_Antibody_Targeted_siRNA_Delivery
Antibody Targeted siRNA Delivery. It is very clear that RNA interference (RNAi) is a potent and versatile tool for gene silencing. One of the hurdles to making siRNA/miRNA a human therapeutic includes effective in vivo delivery and being able to deliver drugs to target cells only.
http://theconversation.com/coronavirus-a-new-type-of-vaccine-using-rna-could-help-defeat-covid-19-133217
Mar 26, 2020 · RNA-based antibodies Besides using mRNA as a vaccine, scientists are also using mRNA as a drug that can be given intravenously. In this case the mRNA encodes an antibody protein that is known to ...
https://www.nature.com/articles/s41467-018-06936-1
Oct 29, 2018 · Here the authors use antibody-coated lipid nanoparticles to deliver mRNA to leukocytes and drive expression of anti-inflammatory cytokines in an inflammatory bowel disease mouse model.Author: Nuphar Veiga, Meir Goldsmith, Yasmin Granot, Daniel Rosenblum, Niels Dammes, Ranit Kedmi, Srinivas R...
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