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https://academic.oup.com/nar/article/43/2/1189/2414709
Dec 30, 2014 · The first reports of antibody-mediated siRNA delivery focused narrowly on individual antibody–antigen interactions and only one or a few cell types. We aimed to study ARC-mediated delivery more broadly and to survey how a variety of properties of the ARCs and targeted cells affected silencing.Author: Trinna L. Cuellar, Dwight Barnes, Christopher Nelson, Joshua Tanguay, Shang-Fan Yu, Xiaohui Wen, Suz...
https://clincancerres.aacrjournals.org/content/21/6/1383
Mar 15, 2015 · Antibody-Mediated Delivery of Anti–KRAS-siRNA In Vivo Overcomes Therapy Resistance in Colon Cancer Sebastian Bäumer , Nicole Bäumer , Neele Appel , Lisa Terheyden , Julia Fremerey , Sonja Schelhaas , Eva Wardelmann , Frank Buchholz , Wolfgang E. Berdel and Carsten Müller-TidowAuthor: Sebastian Bäumer, Nicole Bäumer, Neele Appel, Lisa Terheyden, Julia Fremerey, Sonja Schelhaas, Eva W...
http://www.nature.com/articles/nbt1101
May 22, 2005 · This study demonstrates the potential for systemic, cell-type specific, antibody-mediated siRNA delivery. Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their ...Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
https://www.ncbi.nlm.nih.gov/pubmed/30393262
Nov 28, 2018 · Immunofluorescence staining and quantitative flow cytometry analysis using human HB-EGF-expressing cells showed both antibody-mediated selective cellular targeting and efficient intracellular delivery of conjugated biotin-fluorescence.Author: Shota Tsuchida, Takashi Matsuzaki, Masaki Yamato, Keiji Okuda, Hai Ying Fu, Ryo Araki, Shoji Sanada,...
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30103-2.pdf
Antibody-mediated siRNA Delivery Schneider et al 2 addition of nonspecific endosome-modulating agents such as chloroquine.7 The objective of the present work was to evaluate the use-fulness of bsAbs in combination with dynamic polyconjugates (DPCs) or lipid-based nanoparticles (LNPs) for targeted delivery of siRNA.
https://www.sciencedirect.com/science/article/pii/S2162253116301032
The combination of the bsAb-targeting platform with DPCs facilitated effective antibody-mediated specific siRNA targeting and target mRNA knockdown. The second siRNA delivery option that we investigated applied LNPs composed of a mixture of lipids and cholesterol including defined amounts of PEG-lipids and Dig-PEG-lipids.Author: Britta Schneider, Michael Grote, Matthias John, Alexander Haas, Birgit Bramlage, Ludger M lckenstein...
https://www.sciencedirect.com/science/article/pii/S0168365919307230
In this study, we explored cationic bovine serum albumin (CBSA) conjugated siS100A4 and exosome membrane coated biomimetic nanoparticles (CBSA/[email protected]) that consist of a CBSA/siS100A4 core and an exosome membrane shell.The use of CBSA/[email protected] to suppress postoperative lung metastasis of TNBC was remarkable, and the biomimetic effectively accumulated in the lungs and ...Author: Liuwan Zhao, Chunyan Gu, Ye Gan, Lanlan Shao, Hongwei Chen, Hongyan Zhu
https://pubs.acs.org/doi/abs/10.1021/ja4059525
Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates. Nucleic Acids Research 2015, 43 (2) , 1189-1203. DOI: 10.1093/nar/gku1362. Ying Jiang, Rui Tang, Bradley Duncan, Ziwen Jiang, Bo …Author: Hua Lu, Danling Wang, Stephanie Kazane, Tsotne Javahishvili, Feng Tian, Frank Song, Aaron Sellers, B...
http://www.thno.org/v09p1247.htm
The simultaneous high expression of both antibody-targeted antigen and siRNA-targeted tumor-associated transcript is the most important criterion for antibody-mediated siRNA delivery in cancer . PSMA is known to be upregulated in CRPC cells which were also widely reported to overexpress TRIM24 . In our study, we also found TRIM24 expression to ...Author: Sheng-Jia Shi, Li-Juan Wang, Dong-Hui Han, Jie-Heng Wu, Dian Jiao, Kai-Liang Zhang, Jiang-Wei Chen, ...
https://stm.sciencemag.org/content/4/130/130ra48.full
Apr 18, 2012 · Similar strategies mediated siRNA delivery and gene silencing in vivo into primary lymphocytes via integrin ScFvs (single-chain fragmented antibodies) and to hepatitis B virus (HBV)–infected hepatocytes via HBV surface antigen . However, this approach has not been evaluated for RNA interference (RNAi)–based therapy of malignant tumors.Author: Yan-dan Yao, Tian-meng Sun, Song-yin Huang, Shuang Dou, Ling Lin, Jia-ning Chen, Jian-bin Ruan, Chen...
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