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http://www.nature.com/articles/nbt1101
May 22, 2005 · Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to deliver siRNA to HIV-infected …Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
http://fulltext.calis.edu.cn/nature/nbt/23/6/nbt1101.pdf
specific, antibody-mediated siRNA delivery. There is increasing enthusiasm for developing therapies based on RNA interference (RNAi)— post-transcriptional gene silencing mediated by small RNA duplexes of 19–23 base pairs (bp). The advantage of RNAi lies in its high specificity and potent gene silencing, coupled with the
https://miami.pure.elsevier.com/en/publications/antibody-mediated-in-vivo-delivery-of-small-interfering-rnas-via-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn , Yi Feng, Deborah Palliser, David B. Weiner, Premlata Shankar, Wayne A. Marasco, Judy LiebermanAuthor: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
https://www.nature.com/articles/d42859-019-00086-0
Nov 14, 2019 · Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors Cell type–specific delivery of siRNAs with aptamer-siRNA chimerasAuthor: Christian Schnell
https://www.researchgate.net/publication/7832546_Antibody_mediated_in_vivo_delivery_of_small_interfering_RNAs_via_cell-surface_receptors
Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to deliver siRNA to HIV-infected or ...
https://www.academia.edu/21594638/Antibody_mediated_in_vivo_delivery_of_small_interfering_RNAs_via_cell-surface_receptors
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
https://clincancerres.aacrjournals.org/content/21/6/1383
Mar 15, 2015 · Antibody-Mediated Delivery of Anti–KRAS-siRNA In Vivo Overcomes Therapy Resistance in Colon Cancer. Sebastian Bäumer, Nicole Bäumer, Neele Appel, Lisa Terheyden, ... Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo …Author: Sebastian Bäumer, Nicole Bäumer, Neele Appel, Lisa Terheyden, Julia Fremerey, Sonja Schelhaas, Eva W...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955826/
HIV-based expression vectors may be used to target the same host cells as wild-type HIV, but there is a major challenge with lentiviral vector-mediated shRNA gene delivery in cancer applications because of the lack of an efficient in vivo delivery mechanism.Author: Monica R. Lares, John J. Rossi, Dominique L. Ouellet
https://en.wikipedia.org/wiki/Small_interfering_RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA non-coding RNA molecules, 20-25 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide sequences by degrading mRNA after transcription, preventing ...
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