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http://www.nature.com/articles/nbt1101
May 22, 2005 · Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to deliver siRNA to HIV-infected or ...Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
https://www.researchgate.net/publication/7832546_Antibody_mediated_in_vivo_delivery_of_small_interfering_RNAs_via_cell-surface_receptors
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors Article (PDF Available) in Nature Biotechnology 23(6):709-17 · July 2005 with 285 Reads How we measure 'reads'
https://clincancerres.aacrjournals.org/content/21/6/1383
Mar 15, 2015 · Antibody-Mediated Delivery of Anti–KRAS-siRNA In Vivo Overcomes Therapy Resistance in Colon Cancer. Sebastian Bäumer, Nicole Bäumer, Neele Appel, Lisa Terheyden, ... Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.Author: Sebastian Bäumer, Nicole Bäumer, Neele Appel, Lisa Terheyden, Julia Fremerey, Sonja Schelhaas, Eva W...
http://fulltext.calis.edu.cn/nature/nbt/23/6/nbt1101.pdf
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors Erwei Song1,4, Pengcheng Zhu1,4, Sang-Kyung Lee1, Dipanjan Chowdhury1, Steven Kussman1, Derek M Dykxhoorn1, Yi Feng1, Deborah Palliser1, David B Weiner2, Premlata Shankar1, Wayne A Marasco3 & Judy Lieberman1 Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic ...
https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.21663
Jun 27, 2007 · RNA interference is highly effective at inhibiting HBV gene expression and replication. However, before small interfering RNA (siRNA) can be used in the clinic, it is essential to develop a system to target their delivery. Antibody‐mediated delivery is a novel approach for targeting siRNA to appropriate cells.Author: Wei-Hong Wen, Jia-Yun Liu, Wei-Jun Qin, Jing Zhao, Tao Wang, Lin-Tao Jia, Yan-Ling Meng, Hui Gao, Ca...
https://www.academia.edu/21594638/Antibody_mediated_in_vivo_delivery_of_small_interfering_RNAs_via_cell-surface_receptors
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)31673-2
Tissue-targeted delivery of small interfering RNA (siRNA) must be achieved before RNA interference (RNAi) technology can be used in practical therapeutic approaches. In this study, the potential of apolipoprotein A-I (apo A-I) for the systemic delivery of nucleic acids to the liver is demonstrated using real-time in vivo imaging. As a proof of concept, synthetic siRNAs against hepatitis B ...Author: Soo In Kim, Duckhyang Shin, Tae Hyun Choi, Jong Chan Lee, Gi-Jeong Cheon, Ki-Yong Kim, Mahnhoon Park...
https://miami.pure.elsevier.com/en/publications/antibody-mediated-in-vivo-delivery-of-small-interfering-rnas-via-
Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to deliver siRNA to …Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
https://www.nature.com/articles/d42859-019-00086-0
Nov 14, 2019 · Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors Cell type–specific delivery of siRNAs with aptamer-siRNA chimerasAuthor: Christian Schnell
https://www.ncbi.nlm.nih.gov/pubmed/25589625
Mar 15, 2015 · Antibody-mediated delivery of anti-KRAS-siRNA in vivo overcomes therapy resistance in colon cancer. ... evaluation in vitro. Furthermore, therapeutic activity of the antibody-KRAS-siRNA complexes was examined in in vivo xenograft mouse tumor models. RESULTS: Antibody-siRNA complexes were targeted and internalized via the EGFR receptor ...Author: Sebastian Bäumer, Nicole Bäumer, Neele Appel, Lisa Terheyden, Julia Fremerey, Sonja Schelhaas, Eva W...
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