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https://www.sciencedirect.com/topics/chemistry/micellar-drug
Micelle formation is a natural property of bile acids, which are secreted into the duodenum under physiological conditions and which play an important role in fat absorption by the intestine. Micellar drug formulations are thus an extension of a normal physiological process.
https://www.sciencedirect.com/topics/materials-science/micelle
Micelles are used for targeted drug delivery due to their high drug loading capacity, and opsonization of these micelles with sugar or peptide can also result in receptor-mediated targeted drug or gene delivery. pH and temperature-sensitive copolymers are used to develop intelligent vehicles, which are currently being used for achieving controlled release (Mourya et al., 2011). Intermolecular interaction among the block polymers leads to the formation of micelles…
https://www.unmc.edu/pharmacy/faculty/pharmaceutical-sciences/docs/v5.pdf
One of the first reported examples of unimolecular micelles suitable for drug delivery was a threearm star polymer - composed of mucic acid substituted with fatty acids as a lipophilic inner block and PEO as a hydrophilic outer block.
https://pubs.rsc.org/en/content/articlelanding/2020/py/d0py00082e
The resulting drug-loaded micelles exhibit tunable drug loading capacity and excellent long-term drug-entrapment stability due to the strong affinity between the drug and micelle core, which led to highly efficient drug loading.Author: Chih-Chia Cheng, Ya-Ting Sun, Ai-Wei Lee, Shan-You Huang, Wen-Lu Fan, Yu-Hsuan Chiao, Chih-Wei Chiu,...
https://www.hindawi.com/journals/jdd/2013/340315/
Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug from the harsh environment of the GI tract, (2) release of the drug in a controlled manner at target sites, (3) prolongation of the residence time in the gut by mucoadhesion, and (4) inhibition of efflux pumps to improve the drug …Author: Wei Xu, Peixue Ling, Tianmin Zhang
https://www.ncbi.nlm.nih.gov/pubmed/17168771
The polymeric micelles used for drug delivery in these examples have shown the abilities to attenuate toxicities, enhance delivery to desired biological sites and improve the therapeutic efficacy of active pharmaceutical ingredients.Author: S. R. Croy, G. S. Kwon
https://www.researchgate.net/publication/261697042_Polymeric_micelles_as_drug_delivery_vehicles
Though much progress has been made in drug delivery systems, the design of a suitable carrier for the delivery of hydrophobic drugs is still a major challenge for researchers. The use of micellar solutions of low molecular weight surfactants has been one of the popular methods for the solubilization...
https://www.tandfonline.com/doi/abs/10.1080/10717544.2020.1748760
(2020). Preparation and antitumor evaluation of hinokiflavone hybrid micelles with mitochondria targeted for lung adenocarcinoma treatment. Drug Delivery: Vol. 27, No. 1, pp. 565-574.
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