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https://www.ncbi.nlm.nih.gov/pubmed/11489482
Jul 06, 2001 · Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. Maeda H(1), Sawa T, Konno T. Author information: (1)Department of Microbiology, Kumamoto University School of Medicine, 860-0811, Kumamoto, Japan. [email protected]: Hiroshi Maeda, Tomohiro Sawa, Toshimitsu Konno
https://www.sciencedirect.com/science/article/pii/S0168365901003091
Jul 06, 2001 · This review article describes three aspects of polymeric drugs. The general mechanism of the EPR (enhanced permeability and retention) effect and factors involved in the effect are discussed, in view of the advantages of macromolecular therapeutics for cancer treatment, which are based on the highly selective EPR-related delivery of drug to tumor.Author: Hiroshi Maeda, Tomohiro Sawa, Toshimitsu Konno
https://www.researchgate.net/publication/11852801_Mechanism_of_tumor-targeted_delivery_of_macromolecular_drugs_including_the_EPR_effect_in_solid_tumor_and_clinical_overview_of_the_prototype_polymeric_drug_SMANCS
Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1349-7006.2009.01323.x
Nov 11, 2009 · Here, we report that topical application of small doses of NG enhanced tumor‐targeted delivery of anticancer drugs to a significant extent. At the same time, the therapeutic effect of these anticancer drugs in various solid tumor models was significantly improved.Author: Takahiro Seki, Takahiro Seki, Jun Fang, Hiroshi Maeda, Hiroshi Maeda
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936496/
Maeda H, Sawa T, Konno T. Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. J. Control. Release. 2001; 74:47–61.Author: Xiaojiao Yu, Ian Trase, Muqing Ren, Kayla Duval, Xing Guo, Zi Chen
https://www.researchgate.net/publication/337186997_Overcoming_barriers_for_tumor-targeted_drug_delivery_the_power_of_macromolecular_anticancer_drugs_with_the_EPR_effect_and_the_modulation_of_vascular_physiology
Overcoming barriers for tumor-targeted drug delivery: the power of macromolecular anticancer drugs with the EPR effect and the modulation of vascular physiology
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