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https://www.slideshare.net/gaurav11288/molecular-basis-oftargateddrugdeliverysystemchatap
Dec 05, 2012 · The concept of targeted drug delivery system given by “Paul Ehrlich”, proposed drug delivery as a “magic bullet”. Targeted drug delivery implies for selective and effective localization of pharmacologically active moiety at preselected target(s) in therapeutic concentration. It restrict the entry of drug in non-targeted cells, thus minimizing toxic effects.
https://www.researchgate.net/publication/327367622_Molecular_Drug_Targets_and_Drug_Delivery
The drug molecules are transported in carrier particles which are assumed to be porous spheres. This mode of drug delivery is non-invasive and has less toxic effects on healthy cells and tissues.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/targeted-drug-delivery
Targeted drug delivery by conjugating with a biocompatible polymer allowing better solubility, lower toxicity, and prolonged release forms the basis of cancer medicine. In the past few decades unprecedented endeavors have been made in the development of nanomaterials, such as quantum dots, nanotubes, nanorods, and other variants composed of metals, semiconductors, carbon, …
http://www.authorstream.com/Presentation/chatap-1294169-molecular-basis-of-targated-drug-delivery-system/
Jan 03, 2012 · 15 Carrier System Used For Targeted Drug Delivery Colloidal Carriers 1)Vesicular system: liposomes,niosomes,virosomes,immunoliposomes 2) Microparticulate system: microspheres,nanoparticles Cellular carriers Resealed erythrocytes,serum albumin,antibodies,platlets,leukocytes Supramolecular delivery Micelles,reverse micelle,liquid crystals,lipoprotein …
https://www.pharmatutor.org/articles/drug-targeting-basic-concepts-drug-carrier-systems-review
As the basis of drug development lies in the understanding of the molecular basis of diseases, selective interference with regulatory processes in health and disease by drug targeting will become a powerful technology. Drug targeting can, in this respect,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222591/
Dec 01, 2007 · Design of nanotechnology – based drug delivery Systems. Nanoparticles can be used in targeted drug delivery at the site of disease to improve the uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability.Author: Sarabjeet Singh Suri, Hicham Fenniri, Baljit Singh
http://www.ijpmr.org/pdf/3-Targeted-Drug-Delivery-System-Current-and-Novel-Approach.pdf
With the targeted drug delivery it becomes difficult to target the tumor cells. Advanced techniques and skilled persons are required. Sometimes it may causes toxicity and it is very difficult to maintain stability of dosage forms[10]. 3. Types of targeted drug delivery Targeted drug delivery may be of following types as discussed below.
https://www.sciencedirect.com/book/9780128140291/applications-of-targeted-nano-drugs-and-delivery-systems
Targeted drug delivery systems, which are also made up of nanoscale drug carrier molecules, are designed for improving the communication of cellular as well as molecular components including biodistribution of tumor-targeted drug (chemo) therapeutics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249419/
These systems use ‘contact-facilitated drug delivery’, which involves binding or interaction with the targeted cell membrane. This permits enhanced lipid-lipid exchange with the lipid monolayer of the nanoparticle, which accelerates the convective flux of lipophilic drugs (e.g., paclitaxel) to dissolve through the outer lipid membrane of the nanoparticles to targeted cells ( Guzman et al., 1996 ).Author: Rajesh Singh, James W. Lillard, James W. Lillard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992821/
Mar 23, 2009 · Molecular engineering is thus needed to create molecular conjugates that have specificity and drug potency. In this report, we explored the usage of DNA-based aptamers, selected from cell-SELEX, for the molecular engineering of a ligand-drug conjugate for targeted drug therapy applications.
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