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https://www.jstage.jst.go.jp/article/dds/27/3/27_202/_article
Vaccine delivery into skin, however, is limited by the barrier of stratum corneum, the outermost layer of skin. A variety of technologies have been developed to permeabilize the stratum corneum to enhance vaccine entry into skin. This review provides a summary of some of these technologies that are based on mechanical disruption of stratum corneum.Author: Mitragotri Samir
https://www.who.int/influenza_vaccines_plan/resources/weniger.pdf
RESEARCH ON NEW VACCINE DELIVERY METHODS: FOCUS ON INFLUENZA Bruce G. Weniger, MD, MPH (Associate Editor, Vaccine) Second WHO Consultation on Gl obal Action Plan for Influenza Vaccines ( GAP-II), 12-14 July 2011, Geneva, Switzerland Page 3 of 15 Slides 1-77, plus 12 backups Minority of Reports: ID Less than SC, or Uncertain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
The delivery of vaccines or drugs is not by diffusion as in transdermal delivery systems but by a temporary mechanical disruption of the skin leading to the placement of the drug or vaccine within the epidermis, where it can more readily reach its site of action.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches.Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
https://www.medscape.com/viewarticle/583214_6
Oct 08, 2019 · Cutaneous Delivery of Prophylactic and Therapeutic Vaccines: Historical Perspective and Future Outlook ... is applied in a patch to the epidermis of skin pretreated by mechanical …
https://iai.asm.org/content/73/8/4803
Aug 01, 2005 · However, the lining of the skin by the stratum corneum is a major obstacle to vaccine delivery. In this study we examined the effect of skin barrier disruption on the immune responses to the cross-reacting material CRM197, a nontoxic mutant of diphtheria toxin (DTx) that is considered as a vaccine candidate.Author: S. Godefroy, M. Peyre, N. Garcia, S. Muller, D. Sesardic, C. D. Partidos
https://www.nature.com/articles/nm0402-415
Apr 01, 2002 · Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery Skip to main content Thank you for visiting nature.com.Author: John A. Mikszta, Jason B. Alarcon, John M. Brittingham, Diane E. Sutter, Ronald J. Pettis, Noel G. H...
https://www.pnas.org/content/96/17/9469
Aug 17, 1999 · Cross-linked protein crystals for vaccine delivery. Nancy St. Clair, Bhami Shenoy ... in organic and mixed solvents, and against mechanical disruption and shear ... This was further mixed by using a magnetic flea immediately before subcutaneous injection under the dorsal skin. Blood samples of approximately 1 ml were collected at days 1, 11, 33 ...Author: Nancy St. Clair, Bhami Shenoy, Lawrence D. Jacob, Alexey L. Margolin
https://www.jstage.jst.go.jp/browse/dds/27/3/_contents
Mechanical Disruption of Skin Barrier for Vaccine Delivery Samir Mitragotri. Released: October 30, 2012. p.202-212 Abstract; Full Text PDF[351K] ...
https://www.sciencedirect.com/science/article/pii/S0142961218306392
Vaccine delivery across the skin, which is highly populated by APCs, including DCs, macrophages, and neutrophils, has the potential for effective immunization . Microneedle (MN) arrays have recently been employed as safe and pain-free vehicles for the transcutaneous delivery of biological drugs by mechanical disruption of the stratum corneum ...Author: Huu Thuy Trang Duong, Yue Yin, Thavasyappan Thambi, Thanh Loc Nguyen, V.H. Giang Phan, V.H. Giang Ph...
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