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https://www.sciencedirect.com/science/article/abs/pii/S0169409X1930239X
Here, we discuss the role of macrophages in the initiation and progression of various inflammatory diseases, summarize the leading drugs used to regulate macrophages, and review drug delivery systems designed to target macrophages. We emphasize strategies that are approved for clinical use or are poised for clinical investigation.Author: Wei He, Wei He, Wei He, Neha Kapate, Neha Kapate, Neha Kapate, C. Wyatt Shields, C. Wyatt Shields, S...
https://www.ncbi.nlm.nih.gov/pubmed/23289618
INTRODUCTION: Targeted drug delivery to the macrophages appears to be an attractive proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection.Author: Narendra K Jain, Vijay Mishra, Neelesh Kumar Mehra
https://www.sciencedirect.com/science/article/pii/S0169409X1930239X
Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases ... This section will discuss the key advances, limitations, and future opportunities for macrophage and monocyte-targeting drug delivery strategies for cancer therapy. The targeting strategies are summarized in Fig. 2.Author: Wei He, Wei He, Wei He, Neha Kapate, Neha Kapate, Neha Kapate, C. Wyatt Shields, C. Wyatt Shields, S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880389/
Another obvious concern for monocyte-macrophage based drug delivery relates to possible cytotoxic effects of cell-carriers for target organs. Monocyte-macrophages attracted to the site of pathology by cytokines are known to release ROS that cause cell damage.Author: Anna M. Brynskikh, Yuling Zhao, R Lee Mosley, Shu Li, Michael D. Boska, Natalia L. Klyachko, Alexand...
https://www.frontiersin.org/articles/10.3389/fphar.2019.00022/full
Jan 25, 2019 · In this review we propose an alternative to the strategies/approaches used until now: a novel macrophage-mediated drug delivery method that more accurately fits the term “drug delivery,” via incorporation of both nanomedicine and cellular manipulation. Macrophages are highly mobile cells.Author: Johan Georg Visser, Anton Du Preez Van Staden, Carine Smith
https://www.researchgate.net/publication/264232932_Macrophages_Targeted_Drug_Delivery_as_a_Key_Therapy_in_Infectious_Disease
Macrophages Targeted Drug Delivery as a Key Therapy in Infectious Disease. ... Macrophage and T lymphocyte apoptosis during e xperimental pulmonary.
https://www.academia.edu/2472206/Targeted_drug_Delivery_to_Macrophages
Targeted drug Delivery to Macrophages
https://www.researchgate.net/publication/234068265_Targeted_drug_delivery_to_macrophages
Thus, macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201805557
Oct 11, 2018 · Macrophages hold great potential in cancer drug delivery because they can sense chemotactic cues and home to tumors with high efficiency. However, it remains a challenge to load large amounts of therapeutics into macrophages without compromising cell functions.Author: Weizhong Zhang, Mengzhe Wang, Wei Tang, Ru Wen, Shiyi Zhou, Chaebin Lee, Hui Wang, Wen Jiang, Ian Mi...
https://www.meddocsonline.org/journal-of-nanomedicine/macrophages-mediated-biomimetic-drug-delivery-systems.html
Macrophages as Drug Delivery Cellular Carriers . Recently, the biomimetic delivery system (BDS) has been emerging as a novel strategy to actively carry payloads to the tumor sites. The BDS shows its superiority over other cancer targeted drug delivery systems in the aspects of inherent tumor-homing tendency and biocompatibility [7].
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