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https://cancerres.aacrjournals.org/content/73/2/490
Jan 15, 2013 · Macrophage delivery of an oncolytic virus (Ad[1/PPT-E1A]) abolishes the regrowth of prostate (LUC-LNCaP) tumors following irradiation. Tumor-bearing mice were administered a single dose of 20 Gy RT and then injected intravenously 2 days later with a single dose of either the oncolytic virus (OV) alone or MDMs cotransduced with an HRE-E1/A/B ...Author: Munitta Muthana, Samuel Rodrigues, Yung-Yi Chen, Abigail Welford, Russell Hughes, Simon Tazzyman, Ma...
https://www.ncbi.nlm.nih.gov/pubmed/26164569
Macrophages and their interactions with oncolytic viruses. ... Phagocytic macrophages play an important role in defending against virus infection and they provide an important barrier that can limit the delivery of therapeutic viruses from the injection to the tumour. Within tumours, macrophages generally adopt an immunosuppressive phenotype ...Author: Philip G Jakeman, Thomas E Hills, Kerry D Fisher, Leonard W Seymour
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428400/
Systemic delivery of reovirus in the presence of neutralizing antibodies. Similar to the findings of our biological endpoint clinical study, 38 2 minutes after i.v. injection of reovirus, infectious virus was recovered from both plasma and cells of non–reovirus-immune mice, but could only be recovered from the cellular fraction in virus-immune mice (Figure 1a).Author: Elizabeth Ilett, Timothy Kottke, Oliver Donnelly, Jill Thompson, Candice Willmon, Rosa Diaz, Shane Z...
https://www.sciencedirect.com/science/article/pii/S0022519318305265
3. Macrophage delivery of oncolytic virus. Having established that our mathematical model produces results which are qualitatively similar to experimental data for macrophage infiltration into an avascular tumour spheroid, we now extend it to account for treatment with radiotherapy and macrophage-delivered oncolytic virotherapy.Author: Michael A. Boemo, Helen M. Byrne
https://www.researchgate.net/publication/233745590_Macrophage_Delivery_of_an_Oncolytic_Virus_Abolishes_Tumor_Regrowth_and_Metastasis_After_Chemotherapy_or_Irradiation
Macrophage delivery of an oncolytic virus (Ad[1/PPT-E1A]) abolishes the regrowth of human prostate (LUC-LNCaP) tumors after treatment with the cytotoxic agent, docetaxel (DOX).
https://link.springer.com/10.1007/s00262-020-02495-x
Feb 22, 2020 · Oncolytic virus (OV) therapy is an emerging approach with the potential to redefine treatment options across a range of cancer indications and in patients who remain resistant to existing standards of care, including immuno-oncology (IO) drugs. MEDI5395, a recombinant Newcastle disease virus (NDV), engineered to express granulocyte–macrophage colony-stimulating factor (GM-CSF), …Author: Shannon Burke, Amy Shergold, Matthew J. Elder, Justine Whitworth, Xing Cheng, Hong Jin, Robert W. Wi...
https://en.wikipedia.org/wiki/Oncolytic_immunotherapy
An oncolytic virus is a virus that preferentially infects and kills cancer cells.As the infected cancer cells are destroyed by oncolysis, they release new infectious virus particles or virions to help destroy the remaining tumour. Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour immune system responses.
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