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https://www.nature.com/articles/s41570-017-0063
Aug 09, 2017 · Figure 2: Macromolecular architectures in drug delivery and examples of the methodologies for their synthesis. Figure 3: Common drug delivery methods: oral, intravenous, transdermal and local ...Author: Ashok Kakkar, Ashok Kakkar, Giovanni Traverso, Giovanni Traverso, Omid C. Farokhzad, Ralph Weisslede...
https://link.springer.com/article/10.1023/A:1016084508097
Jun 01, 1996 · This review article describes the current status and future perspectives of site-specific drug delivery by means of macromolecular carrier systems. Basic aspects and recent advances of targeted delivery of 1) conventional drugs, 2) protein drugs, and 3) gene medicines including antisense oligonucleotides and plasmid DNA, are reviewed from a pharmacokintic perspective.Author: Yoshinobu Takakura, Mitsuru Hashida
https://link.springer.com/chapter/10.1007/978-1-59745-532-9_14
Cost-effectiveness suggests that developing an improved delivery system for an existing drug is a better alternative than modifying the chemical structure of the drug or discovering new drug entities. This chapter focuses on macromolecular drugs and their delivery systems including liposomes, polymers, peptides, and nanoparticles.Author: Neelam Azad, Yon Rojanasakul
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613785/
Macromolecular architectures in drug delivery and examples of the methodologies for their synthesis. Some of the common synthetic methods (upper left panel), and chemical reactions and coupling strategies (lower left panel) that have been used for the synthesis of linear, branched and hyperbranched macromolecules and hybrids thereof (right panel) are shown.Author: Ashok Kakkar, Ashok Kakkar, Giovanni Traverso, Giovanni Traverso, Omid C. Farokhzad, Ralph Weisslede...
http://www.pharmtech.com/oral-delivery-macromolecular-drugs
Jul 02, 2018 · Macromolecular drugs, such as peptides, proteins, and antibodies, offer a newer class of drugs that can treat diseases of the GI tract, such as inflammatory bowel disease (IBD). These drugs have demonstrated improved efficacy and represent a new paradigm of treatments for IBD.
https://www.sciencedaily.com/releases/2018/02/180207120629.htm
Feb 07, 2018 · Hong Kong Baptist University (HKBU) scholars demonstrated the design and synthesis of a smart globular macromolecular machine vehicle for actively controlled cancer drug delivery, which would enhance the drug's efficacy. This world-first breakthrough gives insight to targeted therapy drugs …
https://www.sciencedirect.com/science/article/pii/S0168365914007822
However, the ADEPT system is designed toward small and hydrophobic drugs (e.g. doxorubicin), which is not suitable for macromolecular agents like protein etc. Protein drugs, for example enzymes, possess multiple functional groups making it difficult to create a single prodrug from an enzyme while keeping its activity; hence, developing an effective delivery system for macromolecular agents is both an …Author: Junxiao Ye, Junxiao Ye, Meong Cheol Shin, Qiuling Liang, Huining He, Victor C. Yang, Victor C. Yang
https://www.thno.org/v07p3260.htm
Hence, an efficient macromolecular drug delivery system with brain targeting ability is highly desired to treat IS. It has been reported that an ischemic cascade which involves overproduction of reactive oxygen species (ROS), failure of endogenous antioxidants to detoxify these entities, ...
https://www.researchgate.net/publication/319010788_Evolution_of_macromolecular_complexity_in_drug_delivery_systems
Evolution of macromolecular complexity in drug delivery systems. Designing therapeutics is a process with many challenges. Even if the first hurdle — designing a drug that modulates the action of a particular biological target in vitro — is overcome, selective delivery to that …
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