We have collected information about Lysosomal Delivery for you. Follow the links to find out details on Lysosomal Delivery.
https://www.ncbi.nlm.nih.gov/pubmed/22450713
Lysosomal delivery of therapeutic enzymes in cell models of Fabry disease. Marchesan D(1), Cox TM, Deegan PB. Author information: (1)Department of Medicine Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.Author: D. Marchesan, T. M. Cox, P. B. Deegan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327330/
Apr 15, 2012 · Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase. ... Delivery of newly synthesized hydrolases from the endoplasmic reticulum (ER) and the Golgi to lysosomes is therefore critical for proper degradation.Author: Marko Jović, Michelle J. Kean, Zsofia Szentpetery, Gordon Polevoy, Anne-Claude Gingras, Julie A. Bri...
https://www.nature.com/articles/s41587-019-0073-7
Apr 01, 2019 · These engineered pertuzumab variants show increased lysosomal delivery and cytotoxicity towards tumor cells expressing intermediate HER2 levels. In HER2int …Author: Jeffrey C. Kang, Wei Sun, Priyanka Khare, Mostafa Karimi, Xiaoli Wang, Yang Shen, Raimund J. Ober, R...
https://www.lysosomaltx.com/
Lysosomal Therapeutics Inc. (LTI) discovers and develops new therapies for patients with severe neurological diseases. Our strategy leverages the clinically-validated link between lysosome-based genetic disorders and neurodegenerative diseases to establish a unique and effective platform for novel d
https://www.sciencedirect.com/science/article/pii/S1074552111002043
Upon delivery to lysosomes, cytosolic components and organelles encapsulated by autophagosomes are exposed to acidic pH and lysosomal proteases. We have previously demonstrated that several fluorescent proteins derived from corals retain fluorescence in these harsh environments. Among the proteins is Keima, which is endowed with a large Stokes ...Author: Hiroyuki Katayama, Takako Kogure, Noboru Mizushima, Tamotsu Yoshimori, Atsushi Miyawaki
https://worldsymposia.org/worldsymposium-program-events-lysosomal-disease/program-lysosomal-research-care/
WORLDSymposium™ is an annual research conference dedicated to lysosomal diseases. WORLD is an acronym that stands for We’re Organizing Research on Lysosomal Diseases. Each year, WORLDSymposium presents the latest information …
https://www.sciencedirect.com/science/article/pii/S0962892498012707
The availability of lysosomal delivery mutants in a metazoan allows the molecular requirements and cellular pathways to lysosomes to be studied in varied cellular contexts in vivo. Such analyses are significant because protein delivery to lysosomes might involve both …Author: Vett Lloyd, Mani Ramaswami, Helmut Krämer
https://pubs.acs.org/doi/10.1021/jacs.9b03990
A Supramolecular Approach for Modulated Photoprotection, Lysosomal Delivery, and Photodynamic Activity of a Photosensitizer. Indranil Roy. Indranil Roy. Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States. More by Indranil Roy.Author: Indranil Roy, Sharan Bobbala, Ryan Michael Young, Yassine Beldjoudi, Minh T. Nguyen, M. Mustafa Ceti...
https://pubs.acs.org/doi/suppl/10.1021/jacs.9b03990/suppl_file/ja9b03990_si_001.pdf
S3 The kinetic analysis was performed using home written programs in MATLAB1 and was based on a global fit to selected single-wavelength kinetics. The time-resolution is given as w = 300 fs (full width at half maximum, FWHM); the assumption of a uniform instrument response across the
https://www.pnas.org/content/pnas/110/8/2999.full.pdf
Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood–brain barrier Daren Wang a,1, Salim S. El-Amouri , Mei Daia, Chia-Yi Kuanb, David Y. Huic, Roscoe O. Bradyd,2, and Dao Pana,e,2 Divisions of aExperimental Hematology and Cancer Biology and bDevelopmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH ...Author: Daren Wang, Salim S. El-Amouri, Mei Dai, Chia-Yi Kuan, David Y. Hui, Roscoe O. Brady, Dao Pan
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