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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783992/
Feb 22, 2016 · 3. Cell-Penetrating Peptides (CPPs) Facilitate Intracellular Protein Therapy. The availability of CPPs to deliver therapeutically active cargo to the intracellular environment provides a novel platform for the development of medical treatments using molecules that would otherwise be ineffective without cellular entry.Author: Ana Dinca, Wei Ming Chien, Michael T. Chin
https://www.sciencedirect.com/science/article/pii/S0960894X17311952
Thus, we prepared bioreducible dimeric CPP–cargo with apoptotic activity using TatBim peptide, which is a fusion of Tat CPP and Bim peptide derived from Bim apoptosis-inducing protein.11, 12 Dimeric TatBim was prepared by the formation of a disulfide bridge to cleave itself in the reductive intracellular environment, where the glutathione ...Author: Hyungjin Kim, Mizuki Kitamatsu, Takashi Ohtsuki
https://www.sciencedirect.com/science/article/pii/S1740674909000043
Because many protein and peptide drugs have their therapeutic targets inside cells, there is also an important task to bring these drugs into target cells without subjecting them to the lysosomal degradation. This review describes current approaches to the intracellular delivery of protein and peptide drugs.Author: Vladimir Torchilin
https://www.nature.com/articles/nature19764
Oct 12, 2016 · Intracellular delivery of materials has become a critical component of genome-editing approaches, ex vivo cell-based therapies, and a diversity of …Author: Martin P. Stewart, Armon Sharei, Xiaoyun Ding, Gaurav Sahay, Robert Langer, Klavs F. Jensen
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154081
Subsequently, we tested whether the fusion peptide could mediate the intracellular delivery of proteins with high molecular weights at the optimum conditions used for BSA delivery, which included using (BP100) 2 K 8 as the carrier peptide and a peptide/protein molar ratio of 10 at 6 h post-infiltration, The ADH (150 kDa) was selected as a model ...Author: Kiaw Kiaw Ng, Yoko Motoda, Satoru Watanabe, Ahmad Sofiman Othman, Takanori Kigawa, Takanori Kigawa, ...
https://www.nature.com/articles/nrd4363
Aug 08, 2014 · Intracellular delivery of proteins and peptides is a new frontier in delivery research, which could dramatically augment the breadth of targets amenable to biopharmaceutical drug therapy. AbstractAuthor: Samir Mitragotri, Paul A. Burke, Robert Langer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427876/
Broadening the intracellular target space by more effective delivery of protein/peptide drugs could expand the repertoire of antibody–drug conjugates to currently undruggable disease-specific targets and permit tailored drug strategies to stratified subpopulations and personalized medicines.Author: Geoffrey Y Berguig, Anthony J Convertine, Shani Frayo, Hanna B Kern, Erik Procko, Erik Procko, Debas...
http://www.ldbiopharma.com/document/technical/intracellular.pdf
Intracellular delivery of protein and peptide therapeutics Vladimir Torchilin Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA Many proteins and peptides are used as highly specific andeffectivetherapeuticagents.Theiruseis ...
https://pubs.acs.org/doi/10.1021/ja907887z
Gold nanoparticles were coated with a short peptide to promote intracellular delivery of membrane-impermeable proteins. Through microscopy and enzyme assays, we demonstrated the particles were able to transport functional enzymes into a variety of cell lines. Significantly, the transported proteins were able to escape from endosomes. Moreover, these particles showed no apparent cytotoxicity.Author: Partha Ghosh, Xiaochao Yang, Rochelle Arvizo, Zheng-Jiang Zhu, Sarit S. Agasti, Zhihong Mo, Vincent ...
https://www.researchgate.net/publication/303752028_Intracellular_Delivery_of_Proteins_and_Peptides
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