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https://www.lysosomaltx.com/
Lysosomal Therapeutics Inc. (LTI) discovers and develops new therapies for patients with severe neurological diseases. Our strategy leverages the clinically-validated link between lysosome-based genetic disorders and neurodegenerative diseases to establish a unique and effective platform for novel d
https://www.ncbi.nlm.nih.gov/pubmed/22450713
Uptake and delivery of α -Galactosidase A to lysosomes in fibroblasts is mediated by the canonical mannose-6-phosphate receptor pathway, but in endothelial cells …Author: D. Marchesan, T. M. Cox, P. B. Deegan
https://www.naturalmedicinejournal.com/blog/secret-effective-liposomal-delivery
In one study, cellular intake increased 9-fold as the liposome size was decreased from 236 nm to 97 nm, and cellular intake was increased 34-fold at 64 nm. 3 In addition, the therapeutic capabilities of a liposomal delivery system are also related to how fast the body clears the liposomes from the blood.
https://www.ncbi.nlm.nih.gov/pubmed/31101939
Targeted enzyme delivery systems (EDSs) can efficiently cross biological barriers such as blood-brain barrier and provide maximal therapeutic effects with minimal side effects, and hence, offer great clinical benefits over the currently used conventional enzyme replacement therapies.Author: Azam Safary, Mostafa Akbarzadeh Khiavi, Yadollah Omidi, Mohammad A. Rafi
https://www.quicksilverscientific.com/quicksilver-delivery-systems/
The Quicksilver Delivery Systems® signature trademark on our liposomal products sets them apart from other companies and ensures a superior product. By virtue of our smaller, more stable, single-layer spheres, made from high-quality ingredients available, our delivery systems improve upon basic liposomal technology.
https://www.researchgate.net/publication/264613524_A_Lysosome_-_Targeted_Drug_Delivery_System_Based_on_Sorbitol_Backbone_towards_Efficient_Cancer_Therapy
A Lysosome - Targeted Drug Delivery System Based on Sorbitol Backbone towards Efficient Cancer Therapy
https://www.sciencedirect.com/science/article/pii/S0169409X12002980
In recent years, activity in the area of delivery of asODN, siRNA, dsRNA and microRNA has intensified , , and the first clinical trials have begun (see Table 1, below).The new LNP siRNA systems have been taken into the clinic to silence PCSK9, a gene expressed primarily in hepatocytes that modulates low density lipoprotein (LDL) levels in the circulation, resulting in rapid and dramatic ...Author: Theresa M. Allen, Pieter R. Cullis
https://www.ncbi.nlm.nih.gov/pubmed/25233432
The lysosomotropic properties of certain detergents might be of use in lysosome-targeting anticancer drugs and drug delivery system in the future. The present review summarizes the current knowledge on the targeting and permeabilizing properties of lysosomotropic detergents from a cellular and physicochemical perspective.Author: Ana M. Villamil Giraldo, Hanna Appelqvist, Thomas Ederth, Karin Öllinger
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664963/
Dec 01, 2015 · Liposomes present as an attractive delivery system due to their flexible physicochemical and biophysical properties, which allow easy manipulation to address different delivery considerations. Despite considerable research in the last 50 years and the plethora of positive results in preclinical studies,...Author: Lisa Sercombe, Tejaswi Veerati, Tejaswi Veerati, Fatemeh Moheimani, Sherry Y. Wu, Anil K. Sood, Susa...
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