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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
If the drug is planned to a specific part of lungs, then the selected device must be capable enough to generate and deliver the particles/droplets of specific aerodynamic diameter. The devices most commonly used for respiratory delivery includes nebulizers, metered-dose inhalers, and dry powder inhalers.
https://phys.org/news/2015-09-team-drug-delivery-lung.html
Sep 02, 2015 · A small liquid plug in the bronchus is manipulated by air ventilation to deliver drug into the most distant alveoli. Credit: Jinho Kim//Columbia Engineering Researchers from …
https://www.nhlbi.nih.gov/events/2014/targeted-drug-delivery-lung-diseases
Identify key cellular and molecular targets for pulmonary drug delivery and relevant biological barriers to drug safe permeation. Identify, validate and optimize carriers, routes and regimens in terms of efficacy and safety for specific lung diseases. Rapidly identify potentially adverse intracellular and/or systemic off-target effects.
https://www.sciencedirect.com/science/article/pii/S221138351830296X
Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles (NP) with anti-cancer drug. MSC showed a higher drug intake capacity than fibroblasts. In addition, MSC showed predominant lung trapping in both rabbit and monkey.Author: Xusheng Wang, Haiyan Chen, Xiaowei Zeng, Wenpeng Guo, Yu Jin, Shan Wang, Ruiyun Tian, Yanjiang Han, ...
https://www.pharmatutor.org/pdf_download/pdf/Vol.%203,%20Issue%202,%20February%202015,%20PharmaTutor,%20Paper-5.pdf
targeted drug delivery in lung cancer. This paper reviews the till date targeted drug delivery research performed for the treatment of lung cancer. Keywords: Targeted Drug Delivery Systems, Lung Cancer, Nanocarrier INTRODUTION Lung cancer is the most chronic disease among the all other airways and lung disease and one
https://www.tandfonline.com/doi/pdf/10.3109/10717544.2011.595842
higher than those for the curcumin solution, and the Ce for lung was 36.19. Histopathological studies proved C-GMS was efficient and safe to be used as a passive targeted drug delivery system to the lung. Hence, C-GMS has a great potential for the targeted delivery of curcumin to the lung.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687239/
Thus, the drug can directly exert its effects on lung cancer cells before it gets degraded or metabolized. Targeted aerosol delivery can also increase the retention time of the drug in the lungs resulting in improvement of the pulmonary receptor occupancy at the expense of systemic exposure,...
https://www.nature.com/articles/s42003-019-0337-2
Mar 07, 2019 · Targeted drug delivery to specific tissues has the potential to improve efficacy of both small and large molecule therapeutics, and prevent off-target toxicity. Such delivery …Author: Gabriela M. Marchetti, Timothy J. Burwell, Norman C. Peterson, Jennifer A. Cann, Richard N. Hanna, Q...
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