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http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Sep 01, 2017 · Pulmonary drug delivery is receiving increased attention as a non-invasive means for local treatment of a wide range of major lung diseases; this route of administration, however, poses additional challenges for medicinal and formulation chemists.
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
Pulmonary delivery of drug has become an attractive target and of tremendous scientific and biomedical interest in the health care research area as the lung is capable of absorbing pharmaceuticals either for local deposition or for systemic delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
The development of drug delivery systems for pulmonary application requires a detailed knowledge of the lung in its healthy, as well as various diseased states. The lung is composed of more than 40 different cells. The human respiratory system is a complex organ system having a close structure-function relationships.
https://www.pharmatutor.org/articles/targeted-drug-delivery-systems-lung-cancer
Lung is an ideal route for administration of anticancer drug as it provides larger alveolar surface area, low thickness of epithelial barrier & extensive vascularization. Nanoparticles with nanocarriers have possibility of cell-targeted drug delivery with minimal systemic side effect and toxicity.Author: Abdul Waheed, Ankit Gupta, Parth Patel
https://www.pharmaexcipients.com/nanotechnology/multifunctional-nanocarriers-lung-drug-delivery/
The devised strategies are mainly directed at three distinct areas of lung drug delivery, encompassing the delivery of proteins and protein-based materials, either for local or systemic application, the delivery of antibiotics, and the delivery of anticancer drugs—the latter two comprising local delivery approaches.
https://erj.ersjournals.com/content/erj/44/3/765.full.pdf
The lung is a unique organ for drug delivery. Its large surface area, thin epithelium layer and rich blood supply ensure fast drug absorption. These properties offer not only the possibility to treat lung disease, but also allow for the systemic application of drugs.Author: Sabine H. van Rijt, Thomas Bein, Silke Meiners
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