Lipid Peptide Gene Delivery

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Tri-peptide cationic lipids for gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285367/
    Jan 07, 2015 · They have tri-lysine and tri-ornithine as head groups, carbamate group as linker and 12 and 14 carbon atom alkyl groups as tails. These tri-peptide cationic lipids were prepared into cationic liposomes for the study of the physicochemical properties and gene delivery.Author: Yinan Zhao, Yinan Zhao, Shubiao Zhang, Yuan Zhang, Shaohui Cui, Huiying Chen, Defu Zhi, Yuhong Zhen,...

Lipid Nanoparticles for Gene Delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
    In another study, Writer et al. prepared lipid peptide nanocomplexes with Gadolinium-chelated lipid, DNA-binding peptide, and plasmid DNA (Writer et al., 2012). These lipid nanocomplexes can be used for gene delivery and MRI imaging in the brain.Author: Yi Zhao, Leaf Huang

Cytosolic antibody delivery by lipid-sensitive ...

    https://www.nature.com/articles/nchem.2779
    May 22, 2017 · The trapping of antibodies in endosomes often limits their use for intracellular targeting. Now, a single amino acid substitution on a spider-venom peptide has been shown to attenuate the cell ...Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...

Principles of electrostatic interactions and self-assembly ...

    https://www.sciencedirect.com/science/article/pii/S0001868613000973
    The present review discusses self-assembly and structure of aggregates formed in three-component systems of cationic liposomes, cationic peptides or proteins and DNA. We discuss two types of systems, namely lipids with model or reconstituted chromatin (LRC) and lipid/peptide/DNA (LPD) complexes for applications in gene delivery.Author: Nikolay V. Berezhnoy, Nikolay Korolev, Lars Nordenskiöld

Lipid Envelope-Type Nanoparticle Incorporating a ...

    https://pubs.acs.org/doi/10.1021/nn401317t
    Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer. Advanced Functional Materials 2019, 29 (18) , 1807677. DOI: 10.1002/adfm.201807677.Author: Kenji Kusumoto, Hidetaka Akita, Taichi Ishitsuka, Yu Matsumoto, Takahiro Nomoto, Ryo Furukawa, Ayman...

Optimization of a Peptide/Non-cationic Lipid Gene Delivery ...

    https://www.sciencedirect.com/science/article/pii/S1525001601904186
    Here we report the characterization and optimization of a peptide/non-cationic lipid gene delivery system that successfully produces high levels of gene expression when delivered by microinjection into chicken embryos in vivo.In addition to plasmid DNA, the delivery complex consisted of four components: 1) a “condensing” peptide with both hydrophobic and cationic amino acid segments; 2) a ...Author: Kenneth J Longmuir, Sherry M Haynes, Mary E Dickinson, Jason C Murphy, Richard C Willson, Alan J War...

Synthetic materials at the forefront of gene delivery ...

    https://www.nature.com/articles/s41570-018-0039-1
    Sep 21, 2018 · Impressive progress in improving gene delivery has been made in the past decade, and several products have reached the market. ... Fig. 3: Protein-mediated, peptide-mediated and lipid-carrier ...Author: Irene Lostalé-Seijo, Javier Montenegro

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