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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
TRANSEPITHELIAL TRANSPORT OF DRUGS. The development of drug delivery systems for pulmonary application requires a detailed knowledge of the lung in its healthy, as well as various diseased states. The lung is composed of more than 40 different cells. The human respiratory system is a complex organ system having a close structure-function ...
https://erj.ersjournals.com/content/erj/44/3/765.full.pdf
In asthma, for example, drug delivery to the upper airways is needed while for alveolar lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis, it is important to have drug deposition in the deep lung rather than the upper airways. Depositing drugs in …Author: Sabine H. van Rijt, Thomas Bein, Silke Meiners
http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Sep 01, 2017 · Pulmonary drug delivery is becoming increasingly used. When developing pulmonary drugs, pharmaceutical chemists must consider drug absorption, control of particle size, suitable toxicology models, and patient compliance. The author reviews the issues specific to developing drugs designed for pulmonary delivery and considers how—with the right knowledge and expertise—these …
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Pulmonary drug delivery is getting more and more magnitude. This is on account of the specific physiological environment of the lung as an absorption and treatment organ. The development of inhalable insulin can be perceived as a milestone in pulmonary drug delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307981/
Although it is intuitive that physiological processes in the lung (e.g., mucociliary clearance and absorption from the lung) could impact on drugs available locally to treat lung infections, it is difficult to directly evaluate the influence of systemic clearance on local drug exposure in …Author: Tomás Sou, Irena Kukavica-Ibrulj, Fadi Soukarieh, Nigel Halliday, Roger C. Levesque, Paul Williams, ...
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
REFERENCE ID: PHARMATUTOR-ART-1700 INTRODUCTION The delivery of the drug through the respiratory tract is called pulmonary drug delivery. In case of brochodialating drugs, this is advantageous as drug will deliver directly to region where its action is required so that the drug effect will be faster and low dose of drug can be administered through this delivery system and so the side effects ...
https://www.news-medical.net/news/20160701/Advances-in-inhaled-drug-delivery-an-interview-with-Dr-Robert-Clarke.aspx
Jul 01, 2016 · Please use one of the following formats to cite this article in your essay, paper or report: APA. Cashin-Garbutt, April. (2018, August 23). Advances in inhaled drug delivery: an interview with Dr ...
https://www.nhlbi.nih.gov/events/2014/targeted-drug-delivery-lung-diseases
The Division of Lung Diseases (DLD) of the National Heart, Lung and Blood Institute (NHLBI) convened a workshop on September 25-26, 2014 to identify important knowledge gaps and key areas for further development to advance targeted delivery and the effects of drugs and imaging probes in managing and treating lung disease.
https://onlinelibrary.wiley.com/doi/abs/10.1002/bdd.2210
This study exercised our lung delivery and disposition kinetic model to derive the kinetic descriptors for the lung disposition of four drugs [calcitonin, tobramycin, ciprofloxacin and fluticasone propionate (FP)] inhaled via different inhalers from the published PK profile data.Author: Anuja Raut, Sneha Dhapare, Jürgen Venitz, Masahiro Sakagami
https://www.crcpress.com/Drug-Delivery-to-the-Lung/Bisgaard-OCallaghan-Smaldone/p/book/9780367396879
Drug Delivery to the Lung - CRC Press Book This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice.
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