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https://www.atsjournals.org/doi/full/10.1164/ajrccm.161.1.9812094
Jan 01, 2000 · The ability of nebulizers to deliver dextran (nominal molecular mass, 4,000 g/mol) to the lung as an inhaled aerosol is evaluated by in vitro experimental methods and mathematical models. Dextran in isotonic saline was aerosolized by four nebulizer types (Pari LC STAR, Hudson T-Updraft II, Acorn II, and Sonix 2000) at dextran concentrations ⩽ 400 mg/ml and with 2.5- and 4-ml volume fills.Author: Warren H. Finlay, Carlos F. Lange, Malcolm King, David P. Speert
https://www.researchgate.net/publication/12694078_Lung_Delivery_of_Aerosolized_Dextran
Lung delivery of aerosolized dextran is well tolerated and has potential therapeutic benefit in the treatment of cystic fibrosis [51]. Therefore, the mannitol-based formulation used in the present ...
http://europepmc.org/abstract/MED/10619803
Feb 01, 2000 · Dextran in isotonic saline was aerosolized by four nebulizer types (Pari LC STAR, Hudson T-Updraft II, Acorn II, and Sonix 2000) at dextran concentrations </= 400 mg/ml and with 2.5- and 4-ml volume fills. Aerosols inhaled during breath simulation were characterized by in-line phase Doppler anemometry, filter collection, osmometry, and gravimetry.Author: Warren H. Finlay, Carlos F. Lange, Malcolm King, David P. Speert
https://journals.physiology.org/doi/full/10.1152/ajplung.00296.2019
To assess lower respiratory tract delivery of aerosolized therapeutics, mice were exposed to aerosolized fluorescein (FITC)-labeled dextran noninvasively via an aerosolization tower or invasively using a rodent ventilator. The efficiency of delivery to the lower respiratory tracts of mice was 0.01% noninvasively compared with 0.3% invasively.
https://www.jstage.jst.go.jp/article/bpb/41/1/41_b17-00348/_pdf/-char/en
In this study, we examined the usefulness of a tissue-clearing technique for the evaluation of the lung distribution of aerosolized drugs. An aerosol formulation of TexasRed dextran (70 kDa), a model compound of drug carrier for aerosolized drugs, was administered intrapulmonarily to mice using a …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281466/
The field of aerosolized drug application included treatment of lung disease like asthma, chronic obstructive pulmonary disease, cystic fibrosis and lung cancer. The aerosol delivery system has also expanded into the realm of system drug delivery. 38 The optimal target within the lungs for delivery of drugs to the systemic circulation is the ...Author: Capt (Navy) Raymond L. Kao, Weixiong Huang, Claudio M. Martin, Tao Rui
https://www.hindawi.com/journals/bmri/2010/284840/
A novel cationic polymer, dextran-spermine (D-SPM), has been found to mediate gene expression in a wide variety of cell lines and in vivo through systemic delivery. Here, we extended the observations by determining the optimal conditions for gene expression of D-SPM/plasmid DNA (D-SPM/pDNA) in cell lines and in the lungs of BALB/c mice via instillation delivery. <i>In vitro</i> studies showed ...Author: Syahril Abdullah, Wai Yeng Wendy-Yeo, Hossein Hosseinkhani, Mohsen Hosseinkhani, Ehab Masrawa, Rajes...
https://www.researchgate.net/publication/284254926_Diffusion-controlled_drug_delivery_systems
Lung Delivery of Aerosolized Dextran. ... Dextran in isotonic saline was aerosolized by four nebulizer types (Pari LC STAR, Hudson T-Updraft II, Acorn II, and Sonix 2000) ...
https://www.sciencedirect.com/science/article/pii/B9780128157206000101
1. An Overview of Pulmonary Drug Delivery in Lung Cancer Therapy 1.1. Main Advantages. Compared to systemic delivery, aerosol chemotherapy could potentially lead to three main benefits for lung cancer therapy .First, the use of the inhalation route for lung diseases …Author: Rémi Rosiere, Karim Amighi, Nathalie Wauthoz
https://www.sciencedirect.com/science/article/pii/S0168365909001904
Liposomes with DPPC also enhanced the in vitro permeation of FITC dextran (Mw 4400, FD-4) through the calu-3 cell monolayer by reducing the transepithelial electrical resistance and did not harm lung tissues in rats. These findings suggest that liposomes with DPPC enhance pulmonary insulin delivery by opening the epithelial cell space in the ...Author: Sumio Chono, Rie Fukuchi, Toshinobu Seki, Kazuhiro Morimoto
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