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https://www.sciencedirect.com/science/article/pii/S0735109700006148
Thus, local paclitaxel therapy with the double-balloon catheter might be a promising approach for the reduction of restenosis after percutaneous transluminal coronary angioplasty. Study limitations. Local drug delivery in coronary arteries for a period of 10 min would require a device that allows for a residual blood stream through a perfusion lumen.Author: Christian Herdeg, Martin Oberhoff, Andreas Baumbach, Andreas Blattner, Dorothea I Axel, Stephen Schr...
https://www.ncbi.nlm.nih.gov/pubmed/10841250
CONCLUSIONS: Local delivery of paclitaxel resulted in reduced neointimal stenosis and enlargement in vessel size. Both these effects contribute to a preservation of vessel shape and are likely to be caused by a structural alteration of the cytoskeleton.Author: Christian Herdeg, Martin Oberhoff, Andreas Baumbach, Andreas Blattner, Dorothea I Axel, Stephen Schr...
http://www.onlinejacc.org/content/35/7/1969
Jun 01, 2000 · Local paclitaxel delivery for the prevention of restenosis: biological effects and efficacy in vivo Christian Herdeg , Martin Oberhoff , Andreas Baumbach , Andreas Blattner , Dorothea I Axel , Stephen Schröder , Helmut Heinle and Karl R KarschAuthor: Christian Herdeg, Martin Oberhoff, Andreas Baumbach, Andreas Blattner, Dorothea I Axel, Stephen Schr...
http://www.onlinejacc.org/content/accj/35/7/1969.full.pdf
restenosis (6–8). The current study was designed to evalu-ate the effects of locally delivered paclitaxel in an experi-mental rabbit angioplasty model. METHODS 3H-Paclitaxel delivery in porcine hearts. The efficiency of delivering paclitaxel with a double-balloon catheter was assessed ex vivo. In six freshly harvested porcine hearts, theAuthor: Christian Herdeg, Martin Oberhoff, Andreas Baumbach, Andreas Blattner, Dorothea I Axel, Stephen Schr...
https://www.researchgate.net/publication/12477549_Local_paclitaxel_delivery_for_the_prevention_of_restenosis_Biological_effects_and_efficacy_in_vivo
The aim of this study was to evaluate the potential of paclitaxel to prevent restenosis in vivo. Paclitaxel (Taxol) is a microtubule-stabilizing compound with potent antitumor activity. It influences the cytoskeleton equilibrium by increasing...
https://www.nejm.org/doi/full/10.1056/NEJMoa0706356
The THUNDER trial was designed for preliminary evaluation of the safety and efficacy of immediately bioavailable, local paclitaxel for the prevention of restenosis in the superficial femoral and ...Author: Gunnar Tepe, Thomas Zeller, Thomas Albrecht, Stephan Heller, Uwe Schwarzwälder, Jean-Paul Beregi, M....
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