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https://www.nature.com/articles/s41598-019-39269-0
Feb 28, 2019 · ICG conjugation can provide a novel fluorescent drug delivery system for treatment of liver cancer and this system can be used to both diagnose and treat HCC.Author: Yoshinori Inagaki, Takashi Kokudo, Mako Kamiya, Shin-nosuke Uno, Masumitsu Sato, Junichi Kaneko, Nor...
https://link.springer.com/chapter/10.1007%2F978-0-387-49785-3_16
Targeting drugs to the liver may circumvent some of these limitations and enable more effective therapies. This chapter reviews the liver-targeting strategies explored to date and, more specifically, the strengths and weaknesses of various prodrug strategies used for liver-specific drug delivery.
https://www.researchgate.net/publication/331406824_A_novel_liver-specific_fluorescent_anti-cancer_drug_delivery_system_using_indocyanine_green
ICG conjugation can provide a novel fluorescent drug delivery system for treatment of liver cancer and this system can be used to both diagnose and treat HCC. ... Specific aspects of immunotherapy ...
https://ijpsr.com/bft-article/liver-specific-drug-targeting-strategies-a-review/
LIVER SPECIFIC DRUG TARGETING STRATEGIES: A REVIEW Abstract. Drug delivery to liver is one of the most challenging research areas in pharmaceutical sciences. The some physiological barrier such as opsonization, mechanical entrapment by pulmonary vascular bed, uptake by RES represents an insurmountable obstacle for a large number of proteins and ...
http://jpet.aspetjournals.org/content/early/2019/03/18/jpet.118.256156
Activation of hepatic stellate cells (HSCs) is the key step during liver fibrogenesis, and its mechanism has been extensively studied by various cell culture and animal models. Targeted delivery of therapeutic agents to activated HSCs is therefore critical for the successful treatment of liver fibrosis.
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in …
http://jpet.aspetjournals.org/content/312/2/554
Targeting drugs to specific organs, tissues, or cells is an attractive strategy for enhancing drug efficacy and reducing side effects. Drug carriers such as antibodies, natural and manmade polymers, and labeled liposomes are capable of targeting drugs to blood vessels of individual tissues but often fail to deliver drugs to extravascular sites.
https://www.sciencedirect.com/science/article/pii/S0169409X09003238
The first part of the review is concerned with the organ-specific delivery of low molecular drugs using chitosan and its derivatives. The subsequent section considers the recent developments of drug delivery carriers for cancer therapy with special focus on various targeting strategies.
https://weigum.wp.txstate.edu/research/liver-cancer-specific-aptamer-for-image-contrast-and-targeted-drug-delivery/
Liver Cancer-specific Aptamer for Image Contrast and Targeted Drug Delivery Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, particularly in regions where chronic Hepatitis B and C infections are common.
https://www.dovepress.com/nanocarrier-based-therapeutics-and-theranostics-drug-delivery-systems--peer-reviewed-article-IJN
This review focuses on the current research on nanocarrier-based therapeutics and theranostic drug delivery systems excluding the negative consequences of nanotechnology in the field of drug delivery systems. However, clinical developments of theranostics nanocarriers for liver cancer are considered outside of the scope of this article.
http://europepmc.org/patents/PAT/WO0118013
PRODRUGS FOR LIVER SPECIFIC DRUG DELIVERY (PAT ... Another aspect of the invention is the use of the prodrugs to treat diseases that benefit from enhanced drug distribution to the liver and like tissues and cells that express cytochrome P450, including hepatitis, cancer, liver fibrosis, malaria, other viral and parasitic infections, and ...
http://pharmascitech.in/admin/php/uploads/75_pdf.pdf
Liver Targeted Drug Delivery System Targeted drug delivery or site-specific drug delivery system has the potential to increase local drug concentrations and thereby increase the effectiveness of the medicines with fewer side effects. Liver diseases especially liver cancer is one of the most prevalent cancers, with a high mortality.
http://europepmc.org/patents/PAT/EP1210354
PRODRUGS FOR LIVER SPECIFIC DRUG DELIVERY (PAT - EP1210354) ERION Mark D. ... Another aspect of the invention is the use of the prodrugs to treat diseases that benefit from enhanced drug distribution to the liver and like tissues and cells that express …
https://mct.aacrjournals.org/content/molcanther/7/3/579.full.pdf
for targeted drug delivery Albert Lo,1,2 Chin-Tarng Lin,2,3 and ... 580 Novel Peptide for Targeted Drug Delivery to Liver Cancer Mol Cancer Ther 2008;7(3). March 2008 ... Hepatocellular carcinoma cell-specific peptide ligand for € € € € € € € € € € € € € € € € € ...
https://link.springer.com/content/pdf/10.1023%2FA%3A1016053128569.pdf
Purpose. A biodegradable carrier for the liver-specific delivery of drugs was developed using poly-L-glutamic acid (PLGA) modified with galactose (galactosylated PLGA or Gal-PLGA), and its feasibility was investigated in mice. Methods. 111In-PLGA and 111In-Gal-PLGAs were injected in mice and their distribution and biodegradation properties were studied. Results. After intravenous injection ...
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