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https://www.pnas.org/content/109/14/E797
Apr 03, 2012 · Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. David N. Nguyen, Kerry P. Mahon, Ghania Chikh, Phillip Kim, ... Immunostimulatory RNA delivery to PDCs using formulations such as LRNP-II may be useful for antiviral applications, whereas delivery using LRNP-I may be most useful for activating monocytes and MDCs to enhance ...Author: David N. Nguyen, Kerry P. Mahon, Ghania Chikh, Phillip Kim, Hattie Chung, Alain P. Vicari, Kevin T. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325698/
Apr 03, 2012 · Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. ... Immunostimulatory RNA delivery to PDCs using formulations such as LRNP-II may be useful for antiviral applications, whereas delivery using LRNP-I may be most useful for activating monocytes and MDCs to enhance vaccine responses. ...Author: David N. Nguyen, Kerry P. Mahon, Ghania Chikh, Phillip Kim, Hattie Chung, Alain P. Vicari, Kevin T. ...
https://www.pnas.org/content/pnas/109/14/E797.full.pdf
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery David N. Nguyena,1, Kerry P. Mahonb, ... liver immunostimulatory RNA (isRNA) to TLR-expressing cells to ... propyl]-N,N,N-trimethylammonium methylsulfate–RNA delivery system and may provide new tools for the manipulation of TLR responses in vitro and in vivo.Author: David N. Nguyen, Kerry P. Mahon, Ghania Chikh, Phillip Kim, Hattie Chung, Alain P. Vicari, Kevin T. ...
https://www.ncbi.nlm.nih.gov/pubmed/22421433
Apr 03, 2012 · Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. Nguyen DN(1), Mahon KP, Chikh G, Kim P, Chung H, Vicari AP, Love KT, Goldberg M, Chen S, Krieg AM, Chen J, Langer R, Anderson DG. Author information: (1)Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02142, USAAuthor: David N. Nguyen, Kerry P. Mahon, Ghania Chikh, Phillip Kim, Hattie Chung, Alain P. Vicari, Kevin T. ...
https://www.researchgate.net/publication/221708314_Lipid-derived_nanoparticles_for_immunostimulatory_RNA_adjuvant_delivery
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery Article (PDF Available) in Proceedings of the National Academy of Sciences 109(14):E797-803 · March 2012 with 87 Reads
https://dspace.mit.edu/openaccess-disseminate/1721.1/91044
National Institutes of Health (U.S.) (Grant EB00244) MIT Libraries home DSpace@MITAuthor: David N. Nguyen, Kerry P. Mahon, Ghania Chikh, Phillip Kim, Hattie Chung, Alain P. Vicari, Kevin T. ...
http://adsabs.harvard.edu/abs/2012PNAS..109E.797N
These lipidoid formulations, which are materials designed specifically for delivery of isRNA to Toll-like receptors, were superior to the commonly used N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate-RNA delivery system and may provide new tools for …
https://core.ac.uk/display/78056306
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery By David N. Nguyen, Kerry P. Mahon, Ghania Chikh, Phillip Kim, Hattie Chung, Alain P. Vicari, Kevin T. Love, Michael Solomon Goldberg, Steve Chen, Arthur M. Krieg, Jianzhu Chen, Robert Langer and Daniel Griffith Anderson
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short ...Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · By covalent or non-covalent binding of these peptides to small molecules, proteins, DNA, small interfering RNA or even nanoparticles, they could facilitate intracellular delivery of various types ...Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
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