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https://www.sciencedirect.com/science/article/pii/S2211383513000919
The availability of novel lipid excipients with acceptable regulatory and safety profiles coupled with their ability to enhance oral bioavailability has helped in the development of lipid based formulations as a means for drug delivery. Lipid-based drug delivery (LBDD) systems have gained much importance in the recent years due to their ability ...Author: Sandeep Kalepu, Mohanvarma Manthina, Veerabhadhraswamy Padavala
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590796/
May 19, 2014 · 2. General Routes of LBDDS. Routes like oral, parenteral, ocular, intranasal, dermal/transdermal, and vaginal can be for the administration of the lipid-based drug delivery systems (LBDDS) [4, 5].However, oral route is the most preferred route because of the properties like noninvasiveness, less expensive, and less prone to side effects, such as injection-site reactions.Author: Kent Jørgensen, Jesper Davidsen, Charlotte Vermehren, Sven Frøkjær, Ole G. Mouritsen
https://www.hindawi.com/journals/jphar/2014/801820/
The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs.Author: Kent Jørgensen, Jesper Davidsen, Charlotte Vermehren, Sven Frøkjær, Ole G. Mouritsen
https://www.sciencedirect.com/science/article/pii/S0927776507003888
PC-LM will be more suitable as an emulsifier or a pharmaceutics material than lecithin used in conventional products when used for intravenous injections. These results of this study will be useful for preparation of fat emulsions and lipid emulsions in drug delivery systems.Author: Emi Kawaguchi, Ken-ichi Shimokawa, Fumiyoshi Ishii
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011075/
Oct 26, 2010 · This drug delivery approach finds its roots in the now well-established parenteral nutrition formulations. In this review, a brief overview of the parenteral lipid emulsions and the various facets in the development of injectable lipid emulsions for drug delivery has been discussed.Author: Ketan Hippalgaonkar, Soumyajit Majumdar, Viral Kansara
https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.1987.tb45793.x
Lipid Emulsions as Drug Delivery Systems. STANLEY S. DAVIS. Pharmacy Department University of Nottingham Nottingham, United Kingdom. Search for more papers by this author. CLIVE WASHINGTON. Pharmacy Department University of Nottingham Nottingham, United Kingdom.Author: Stanley S. Davis, Clive Washington, Philip West, Lisbeth Illum, Garry Liversidge, Larry Sternson, Ri...
https://www.tandfonline.com/doi/abs/10.1517/17425247.2014.935335
Nov 02, 2012 · Introduction: Compritol® 888 ATO is a lipid excipient that is generally used in cosmetic industry as a surfactant, emulsifying agent and viscosity-inducing agent in emulsions or creams. Based on its chemical composition, Compritol 888 ATO is a blend of different esters of behenic acid with glycerol.Areas covered: Recently, there has been great interest in the multiple roles that Compritol 888 ...Author: Mona H Aburahma, Shaimaa M Badr-Eldin
https://drug-dev.com/lipid-based-delivery-are-lipid-based-drug-delivery-systems-in-your-formulation-toolbox/
ABSTRACT. This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
https://www.longdom.org/open-access/selfemulsifying-drug-delivery-systems-sedds-in-pharmaceuticaldevelopment-2090-4568-1000130.pdf
solubility in lipid-based systems [12], mixed micelles [13,14] and the use of silica-based mesoporous materials [15-19] have been the main approaches studied. Lipid-based formulations include lipid solutions, lipid nanoparticles, emulsions, microemulsions or Self-Emulsifying Drug Delivery Systems (SEDDS), as seen in Figure 1 [20-22]. AlthoughFile Size: 540KB
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