Exubera Pulmonary Insulin Delivery System

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Evolution of a Pulmonary Insulin Delivery System (Exubera ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925008/
    The Exubera Device. Exubera (INH) is a novel inhaled insulin delivery system that has been developed for prandial insulin use in patients with type 1 or type 2 diabetes. The INH system has 3 main components: a dry powder formulation of human insulin, packaged in foil blisters for long-term stability; the insulin inhaler device with a holding chamber that facilitates appropriate and consistent ...Author: Priscilla A. Hollander

Evolution of a pulmonary insulin delivery system (Exubera ...

    https://www.ncbi.nlm.nih.gov/pubmed/17435648
    Mar 05, 2007 · 1. MedGenMed. 2007 Mar 5;9(1):45. Evolution of a pulmonary insulin delivery system (Exubera) for patients with diabetes. Hollander PA(1). Author information: (1)Baylor University Medical Center, Endocrinology Center, Dallas, Texas, USA. [email protected] Many patients with diabetes fail to meet recommended glycemic goals regardless of the recognition of optimal glycemic …Author: Priscilla A. Hollander

Development of the Exubera® Insulin Pulmonary Delivery System

    https://www.researchgate.net/publication/286554041_Development_of_the_ExuberaR_Insulin_Pulmonary_Delivery_System
    The aim of this study was to determine whether premeal pulmonary delivery of rapid-acting, dry-powder insulin (Exubera) plus Ultralente could provide glycemic control comparable to a conventional ...

Development of the Exubera® Insulin Pulmonary Delivery System

    https://link.springer.com/chapter/10.1007%2F978-1-4614-9524-6_21
    Feb 04, 2014 · Abstract. Development of Exubera® (insulin powder for inhalation) presented numerous challenges as a first-in-class product. These challenges included developing (a) the first room temperature stable insulin formulation, (b) a spray-drying process to produce a fine respirable powder with the physical attributes needed for efficient aerosolization, (c) a filling and packaging process …Author: Cynthia L. Stevenson, David B. Bennett

REFERENCES - UpToDate

    https://www.uptodate.com/contents/inhaled-insulin-therapy-in-diabetes-mellitus
    Pfützner A, Forst T. Pulmonary insulin delivery by means of the Technosphere drug carrier mechanism. Expert Opin Drug Deliv 2005; 2:1097. Brain J, Finch GL, Rice RJ, et al. Trough insulin levels in bronchoalveolar lavage following inhaltion of human insulin (Exubera) in patients with diabetes mellitus.

The Design and Performance of the Exubera® Pulmonary ...

    https://www.liebertpub.com/doi/10.1089/dia.2007.0222
    The Exubera ® system (Pfizer, New York, NY/Nektar Therapeutics, San Carlos, CA) is an integration of five major new technologies: protein formulation, powder processing, powder filling, drug packaging, and delivery device. The product provides a simple interface, where the patient interacts only with the delivery device and powder packaging.Author: Nancy J. Harper, Steven Gray, Jennifer De Groot, Joann M. Parker, Negar Sadrzadeh, Carlos Schuler, J...

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