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https://www.researchgate.net/publication/224924770_Lipid-Based_Nanoparticles_for_siRNA_Delivery_in_Cancer_Therapy_Paradigms_and_Challenges
Request PDF Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges RNA interference (RNAi) is a specific gene-silencing mechanism that can be …
https://www.medscape.com/viewarticle/818963_7
Mar 25, 2020 · Moving forward, we expect that lipid-based NPs will have a key role in systemic application of siRNA in the clinic. In particular, it will have an enabling role for personalized cancer …
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2009.02189.x
Herein, we review the molecular and structural parameters of lipid‐based siRNA delivery systems. Citing Literature. ... , Recent progress in development of siRNA delivery vehicles for cancer therapy, Advanced Drug Delivery ... of phosphatidylcholine–sodium cholate-based nanoparticles for siRNA delivery to MCF-7 ...
https://www.researchgate.net/publication/313220104_Lipid-based_nanoparticles_for_cancer_treatment
322 CHAPTER 8 Lipid-based nanoparticles for cancer treatment intravenous administration of SNAL P/anti-PLK1 siRNA twice a week for 3 weeks resulted in notable and significant tumor growth ...
https://www.intechopen.com/books/antisense-therapy/applications-of-lipidic-and-polymeric-nanoparticles-for-sirna-delivery
Lipid-based siRNA delivery systems include liposomes, micelles, microemulsions, ionizable lipids and lipid nanoparticles, and solid lipid nanoparticles. 3.1.1 Liposomes Liposomes are spherical vesicles consisting of an aqueous core together with a bilayer phospholipid structure which contain natural body components (e.g., lipids, sterols) and ...
https://www.nature.com/articles/ncomms5277
Jun 27, 2014 · In order to develop efficacious, degradable nanoparticles for siRNA delivery while conducting structure–function analysis, we first employed Michael addition chemistry to …
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0683-y
Jul 28, 2017 · Generally, cationic lipids have been used as siRNA delivery carriers because they associate easily with negatively charged nucleic acids . The physicochemical properties of lipid-based nanoparticles (e.g., the structure, size, and surface charge) may be optimized by modifying the lipid composition, drug-to-lipid ratio, and manufacturing process.
https://www.hindawi.com/journals/bmri/2013/782041/
In this review, the authors discuss recent advances in nanoparticle-mediated siRNA delivery systems and the application of these systems in clinical trials for cancer therapy. Furthermore, we offer perspectives on future applications of siRNA therapeutics. 2. Lipid-Based Nanovectors for Systemic siRNA Delivery 2.1. Liposomes/Lipoplexes
https://medcraveonline.com/MOJPB/sirna-based-nanoparticles-for-cancer-therapy-hurdles-and-hopes.html
Nov 24, 2016 · The objectives of this article are to (a) explain siRNA mechanism in the context of cancer therapy; (b) highlight the usefulness of nanoparticles-based delivery, and (c) review the prospects and challenges of the ongoing siRNA-based clinical research. Keywords: no particles, siRNA, cancer therapy, delivery strategies, clinical trials
https://www.thno.org/v06p0192.pdf
peutics, systemic delivery of siRNA has shown only limited success in cancer therapy. Cationic lipid-based nanoparticles have been widely used for this purpose, but their toxicity and undesired liver uptake after systemic injection owing to their cationic surfaces have hampered further clinical translation.
https://link.springer.com/article/10.1007/s11095-006-9180-5
Jan 25, 2007 · Lipid-based colloidal particles have been extensively studied as systemic gene delivery carriers. The topic that we would like to emphasize is the formulation/assembly of lipid-based nanoparticles (NP) with diameter under 100 nm for delivering nucleic acid in vivo. NP are different from cationic lipid–nucleic acid complexes (lipoplexes) and are vesicles composed of lipids and …
http://pharmrev.aspetjournals.org/content/68/3/701
However, the application of nanotechnology has led to the development of effective nanosized drug delivery systems known commonly as nanoparticles. Among these delivery systems, lipid-based nanoparticles, particularly liposomes, have shown to be quite effective at exhibiting the ability to: 1) improve the selectivity of cancer chemotherapeutic ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30188-5
Moreover, acquired resistance to antiangiogenic therapy often develops and restricts the therapeutic efficacy of this treatment. Hence, in this study, we develop a CXCR4-targeted lipid-based nanoparticle (NP) formulation to specifically deliver vascular endothelial growth factor (VEGF) siRNA as an antiangiogenic substance into HCC.
https://www.semanticscholar.org/paper/siRNA-based-Nanoparticles-for-Cancer-Therapy%3A-and-Moffatt/71865289ad0489402ac2742e49c1796d9db46846
The objectives of this article are to (a) explain siRNA mechanism in the context of cancer therapy; (b) highlight the usefulness of nanoparticles-based delivery, and (c) review the prospects and challenges of the ongoing siRNA-based clinical research.
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(19)30184-4
Apr 24, 2019 · Yin et al. utilized a stable three-way junction (3WJ) motif as a scaffold, further functionalized with CD133 aptamer, anti-miR21, and Alexa647 fluorophore, for triple-negative breast cancer targeting and therapy. The multifunctional RNA nanoparticles were capable of inhibiting tumor growth in a mouse model with undetectable toxicity.
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