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https://www.genomics-online.com/plasmid/lentiviral-vectors/
Why use Lentiviral Vectors? Lentiviruses are a subclass of Retroviruses. They derived from the human immunodeficiency virus (HIV-1) and became suitable tools for gene delivery in mammalian cells, with most of the viral genes removed.Lentiviral vectors can be used for introducing libraries of complementary DNAs, short hairpin RNAs, and cis-regulatory elements into many targets, including ...
https://www.researchgate.net/publication/10912759_Lentiviral_Vectors_for_Gene_Delivery_into_Cells
Lentiviral Vectors for Gene Delivery into Cells Article · Literature Review in DNA and Cell Biology 21(12):937-51 · January 2003 with 11 Reads How we measure 'reads'
https://www.liebertpub.com/doi/abs/10.1089%2F104454902762053873
Jul 06, 2004 · These vectors are also appropriate for the study of other viruses (specifically of viral entry) and investigation of the HIV replicative cycle, along with straightforward transgene delivery to target cells of interest. Vectors based upon other lentiviruses have shown similar abilities and promise.Author: Ricardo Quinonez, Richard E. Sutton
https://www.nature.com/articles/s41375-018-0106-0
Mar 22, 2018 · The safety of lentiviral vectors in ex vivo gene transfer into HSCs remains a somewhat open question; however, the field has now gained over 10 …Author: Michael C. Milone, Una O’Doherty
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583925/
Jan 01, 2013 · Among currently available gene delivery vehicles, lentiviral vectors (LVs) are unique in mediating long-term gene expression in resting as well as proliferating cells of the hematopoietic system. Moreover, genetic modifications introduced into stem cells will …Author: Qi Zhou, Christian J. Buchholz
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)32420-0
In this study, we demonstrated that human immunodeficiency virus type 1-based lentiviral vectors support efficient and stable gene delivery into primary murine NK cells. Using a single-step transduction protocol, we were able to achieve an average of 40% transduction efficiency on primary NK cells.Author: Jimmy Tran, Sam Kp Kung
https://www.sciencedirect.com/science/article/pii/S1079979603000627
Furthermore, the ease of the multiple delivery of genes with lentiviral vectors into primary hematopoietic and leukemia cells will be an advantageous method for evaluating the influence of different genes in multi-factorial pathways, e.g., signal transduction pathways, cell cycle control, and apoptosis.Author: Renata Stripecke, Richard C. Koya, Huy Q. Ta, Noriyuki Kasahara, Alexandra M. Levine
https://www.sciencedirect.com/science/article/pii/S1525001616324200
The use of adenoviral vectors as vehicles for gene delivery into NK cells is ineffective because NK cells do not express the appropriate receptors required for transduction. 28 Non-viral-based gene transfer methods such as transfection and particle-mediated gene gun delivery showed inefficient gene delivery into NK cells, and the genetic ...Author: Jimmy Tran, Sam Kp Kung
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