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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937993/
Viral vector delivery of factor VIII (FVIII) cDNA has the potential to alleviate the debilitating clotting defects. Lentiviral-based vectors delivered to murine models of hemophilia A mediate phenotypic correction. However, a limitation of lentiviral-mediated FVIII delivery is …Author: Staber Jm, Staber Jm, Pollpeter Mj, Pollpeter Mj, Anderson Cg, Burrascano M, Cooney Al, Cooney Al, S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697098/
Evaluation of macrophage-specific promoters using lentiviral delivery in mice. ... 6 Macrophage-specific promoters (MSPs) can be used for gene delivery approaches as valuable tools to study the function of the macrophage per se, or to treat diseases in a macrophage-dependent fashion.Author: Malin C. Levin, Ulf Lidberg, Pernilla Jirholt, Martin Adiels, Anna Wramstedt, Kenth Gustafsson, Davi...
https://www.nature.com/articles/gt2011195
Dec 01, 2011 · Evaluation of macrophage-specific promoters using lentiviral delivery in mice. M C Levin 1,2, U Lidberg 1,2, P Jirholt 3, M Adiels 1,2, A Wramstedt 1,2, K Gustafsson 4, D R Greaves 5,Author: Malin C. Levin, Ulf Lidberg, Pernilla Jirholt, Martin Adiels, Anna Wramstedt, Kenth Gustafsson, Davi...
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · However, gene delivery to kidney cells is inefficient. ... Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections. ... vectors to deliver genes to renal cells. When vectors were delivered by the intravenous (IV) route in mice, weak luciferase activity was observed in the kidney with substantially more in ...Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.sciencedirect.com/science/article/pii/S1525001605011111
Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice. ... All mice treated with the HR′SIN-cPPT-S-FIX-W vector showed normal liver morphology, as did the biopsies from normal liver tissue in tumor-bearing and control animals.Author: Mike Themis, Simon N. Waddington, Manfred Schmidt, Christof von Kalle, Christof von Kalle, Yoahe Wan...
https://www.labome.com/method/Nucleic-Acid-Delivery-Lentiviral-and-Retroviral-Vectors.html
A review and guide of lentiviral and retroviral vectors for nucleic acid delivery In recent years, retroviral and lentiviral vectors have become increasingly vital tools for the delivery of nucleic acids to many cell types in a variety of experimental systems.Author: Erin P O’Keefe
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/lentivirus-vector
Deepa H. Patel, Ambikanandan Misra, in Challenges in Delivery of Therapeutic Genomics and Proteomics, 2011. 5.6.2 Lentivirus. Lentiviral vectors are a type of retrovirus that can infect both dividing and nondividing cells because their preintegration complex (virus “shell”) can get through the intact membrane of the nucleus of the target cell.
https://www.jove.com/video/58327/laser-assisted-lentiviral-gene-delivery-to-mouse-fertilized-eggs
Mouse fertilized eggs and early stage embryos are protected by the zona pellucida, a glycoprotein matrix that forms a barrier against gene delivery. This article describes a protocol for perforating the zona with a laser to transduce embryonic cells with lentiviral vectors and to create transgenic mice…Author: Negin P. Martin, Page Myers, Eugenia Goulding, Shih-Heng Chen, Mitzie Walker, Thomas M. Porter, Luca...
https://www.sigmaaldrich.com/life-science/functional-genomics-and-rnai/shrna/in-vivo.html
Biodistribution of MISSION in vivo lentivirus. MISSION lentivirus can transduce a variety of organs and tissues in vivo through multiple routes of delivery. Figure 1 shows the results of a proof-of-principle experiment in mice using a lentivirus expressing far-red fluorescent protein.
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