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https://www.ncbi.nlm.nih.gov/pubmed/10699266
Mar 01, 2000 · Rather than only acting as a platform for controlled release systems, the concept of lectin-mediated bioadhesion therefore bears the potential for the controlled delivery of macromolecular biopharmaceuticals at relevant biological barriers, such as the …Author: Claus-Michael Lehr
https://www.sciencedirect.com/science/article/pii/S0169409X0300231X
4.3. Lectins for drug delivery within the oral cavity. The use of lectins for drug delivery within the oral cavity is still an undeveloped area. To confer a therapeutic advantage, lectin-containing delivery systems would have to: • bind rapidly and be retained for extended periods and/or; • locate and target a specific location; •Author: John D. Smart
https://www.ncbi.nlm.nih.gov/pubmed/12575733
Lectin-mediated drug delivery may become a promising strategy to improve the efficacy of poorly permeable drugs by utilising active high-capacity transport pathways of epithelial tissues. This requires the elucidation of the basic mechanisms of lectin uptake prior to their practical use.Author: M. Wirth, C. Kneuer, C.M. Lehr, F. Gabor
https://www.sciencedirect.com/science/article/pii/S016836599900228X
Mar 01, 2000 · Rather than only acting as a platform for controlled release systems, the concept of lectin-mediated bioadhesion therefore bears the potential for the controlled delivery of macromolecular biopharmaceuticals at relevant biological barriers, such as the …Author: Claus-Michael Lehr
https://www.sciencedirect.com/science/article/pii/S0378517302000492
Apr 26, 2002 · But most of the conjugate is taken up into differentiated cells and processed as in single cells. Though the enzymic barrier remains to be surmounted, WGA-mediated drug delivery is a promising strategy for peroral delivery of even high molecular weight drugs to overcome the mucosal barrier.Author: Franz Gabor, Andrea Schwarzbauer, Michael Wirth
https://www.researchgate.net/publication/279564084_Lectin-mediated_drug_delivery_Fundamentals_and_perspectives
Apart from the genetic and the peptide code, the sugar code appears more and more as a possible mailing system for biological information, Relying on carbohydrate-protein interactions, lectin-mediated drug delivery is a promising strategy to improve the efficacy of poorly absorbable drugs by opening endocytic pathways.
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